Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMAIJSX)

Drug Name
L-701324 Drug Info
Synonyms
L-701324; 142326-59-8; L-701,324; L 701324; UNII-I9WY146163; C21H14ClNO3; L 701,324; CHEMBL31741; 7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolone; I9WY146163; 7-Chloro-4-hydroxy-3-(3-pheoxyphenyl)-2(1H)-quinolinone; 2(1H)-Quinolinone, 7-chloro-4-hydroxy-3-(3-pheoxyphenyl)-; SMR000326934; compund 13 [PMID: 8182696]; Tocris-0907; AC1L3GJN; Biomol-NT_000206; MLS002153302; MLS000860076; GTPL4240; SCHEMBL1998890; BPBio1_001264; CHEBI:92140; DTXSID00162016; EX-A587; MolPort-003-941-887; 2(1H)-Quinolinone, 7-chloro-4-hydroxy-3-(3-ph
Cross-matching ID
PubChem CID
54682505
ChEBI ID
CHEMBL92140
CAS Number
CAS 142326-59-8
TTD Drug ID
D0M1WN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Nucleotide excision repair 2.10 0.00e+0 40/47 (85.11%) PCNA;RAD23B;XPA;...
Ribosome 1.89 1.15e-2 113/158 (71.52%) MRPL33;MRPL20;RPL36AL;...
T cell receptor signaling pathway 1.82 4.59e-2 93/104 (89.42%) ICOS;ITK;MAPK13;...
Terpenoid backbone biosynthesis -1.64 3.90e-2 18/22 (81.82%) MVK;PMVK;DHDDS;...
Renin-angiotensin system -1.66 3.42e-2 20/23 (86.96%) KLK1;CTSG;CTSA;...
Galactose metabolism -1.72 1.87e-2 26/31 (83.87%) GAA;SI;MGAM;...
Sulfur relay system -1.73 1.88e-2 5/8 (62.5%) TST;MPST
Synthesis and degradation of ketone bodies -1.74 1.83e-2 9/10 (90%) ACAT2;HMGCS2;HMGCS1
Metabolism of xenobiotics by cytochrome P450 -1.77 9.22e-3 49/77 (63.64%) GSTM4;CYP2E1;GSTK1;...
Steroid hormone biosynthesis -1.78 7.85e-3 43/61 (70.49%) CYP2E1;DHRS11;CYP3A7;...
Glycerolipid metabolism -1.79 8.56e-3 44/61 (72.13%) AGPAT5;DGKZ;DGKI;...
Nitrogen metabolism -1.81 7.70e-3 16/17 (94.12%) CPS1;CA4;GLUL;...
Bile secretion -1.81 8.56e-3 68/90 (75.56%) SLC9A1;SCARB1;BAAT;...
Drug metabolism -1.81 9.63e-3 78/151 (51.66%) FMO5;GSTM4;CYP2E1;...
PPAR signaling pathway -1.82 9.78e-3 66/74 (89.19%) SLC27A2;NR1H3;FABP2;...
Tyrosine metabolism -1.86 5.71e-3 30/36 (83.33%) GOT2;ADH6;HGD;...
Retinol metabolism -1.88 5.14e-3 41/68 (60.29%) CYP3A7;CYP2C9;ADH1A;...
Ascorbate and aldarate metabolism -2.00 0.00e+0 15/30 (50%) UGT2B4;UGT2B15;UGDH;...
Complement and coagulation cascades -2.02 0.00e+0 76/85 (89.41%) C3;PROS1;PROC;...
Porphyrin and chlorophyll metabolism -2.09 0.00e+0 23/43 (53.49%) ALAS1;COX15;HEPH;...
Pentose and glucuronate interconversions -2.27 0.00e+0 17/34 (50%) DCXR;UGT2B4;UGT2B15;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 3.33uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H