Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMAJPOX)

Drug Name
Balapiravir Drug Info
Synonyms
Balapiravir hydrochloride; HCV NS5B polymerase inhibitor, Roche; RO4588161-001; RNA polymerase inhibitor (HCV infection), Roche; RNA polymerase inhibitor (hepatitis C infection), Roche; R-1479 prodrug (HCV infection), Roche
Cross-matching ID
PubChem CID
11691726
CAS Number
CAS 690270-29-2
TTD Drug ID
D01FUL

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.06 0.00e+0 93/133 (69.92%) ATP6V1D;NDUFB5;SDHD;...
Parkinson disease 1.87 3.32e-2 176/249 (70.68%) UCHL1;NDUFB5;CYCS;...
Prion disease 1.80 4.74e-2 209/273 (76.56%) HSPA8;NDUFB5;CYCS;...
IL-17 signaling pathway 1.80 3.55e-2 84/94 (89.36%) S100A9;S100A8;S100A7;...
Terpenoid backbone biosynthesis 1.77 4.36e-2 18/22 (81.82%) ACAT2;IDI1;PCYOX1;...
ECM-receptor interaction -1.75 4.85e-2 80/88 (90.91%) COL1A2;SDC4;COL6A2;...
Primary immunodeficiency -1.81 2.64e-2 33/38 (86.84%) ZAP70;AICDA;IGLL1;...
VEGF signaling pathway -1.84 2.46e-2 50/59 (84.75%) PTGS2;AKT1;PIK3CD;...
Notch signaling pathway -2.07 5.28e-3 49/59 (83.05%) MAML1;TLE1;JAG2;...
Asthma -2.17 0.00e+0 25/31 (80.65%) IL3;IL13;EPX;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H