Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMAKIDV)

• Drug Name: Dydrogesterone Drug Info
• Synonyms: Dehydrogesterone; Didrogesterona; Didrogesterone; Diphaston; Dufaston; Duphaston; Duvaron; Dydrogesterona; Dydrogesteronum; Gestatron; Gynorest; Hydrogesterone; Hydrogestrone; Isopregnenone; Prodel; Retrone; Terolut; Didrogesterone [DCIT]; Solvay Brand of Dydrogesterone; DELTA6-Retroprogesterone; Duphaston (TN); Dydrogesterona [INN-Spanish]; Dydrogesteronum [INN-Latin]; Gynorest (TN); Delta(6)-Retroprogesterone; Delta(sup 6)-Retroprogesterone; Retro-6-dehydroprogesterone; Dydrogesterone (JP15/USP/INN); Dydrogesterone [USAN:INN:BAN:JAN]; Pregna-4,6-diene-3,20-dione, (9-beta,10-alpha)-(9CI); (8S,9R,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one; (9-beta,10-alpha)-Pregna-4,6-diene-3,20-dione; (9beta,10alpha)-pregna-4,6-diene-3,20-dione; 10alpha-Isopregnenone; 6 Dehydro 9 beta 10 alpha progesterone; 6-Dehydro-9 beta-10 alpha-progesterone; 6-Dehydro-9.beta.,10.alpha.-progesterone; 6-Dehydro-9beta,10alpha-progesterone; 6-Dehydro-retro-progesterone; 6-Dehydroretroprogesterone; 9-.beta.,10.alpha.-Pregna-4,6-diene-3,20-dione; 9-beta,10-alpha-Pregna-4,6-diene-3,20-dione; 9-beta,10alpha-Pregna-4,6-diene-3,20-dione; 9.beta.,10.alpha.-Pregna-4,6-diene-3,20-dione; 9beta,10alpha-Pregna-4,6-diene-3,20-dione; 9beta,10alpha-Pregna-4,6-diene-3,20-dione (8CI)
• Therapeutic Class: Progesterones
• Cross-matching ID:
  PubChem CID: 9051
  ChEBI ID: CHEMBL31527
  CAS Number: CAS 152-62-5
  TTD Drug ID: D0F1UL
  INTEDE Drug ID: DR0556

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Ribosome	2.02	8.29e-3	113/158 (71.52%)	RPS5;RPL36;RPS27L;...
Endocytosis	-1.69	3.12e-2	198/252 (78.57%)	ARF5;SH3GL2;ARAP1;...
Sulfur metabolism	-1.73	2.09e-2	9/10 (90%)	SUOX;MPST;SQOR;...
Epstein-Barr virus infection	-1.74	1.77e-2	189/202 (93.56%)	HLA-DRB1;ITGAL;IKBKG;...
Antigen processing and presentation	-1.75	1.48e-2	60/78 (76.92%)	NFYC;HLA-DQB1;HSP90AB1;...
Graft-versus-host disease	-1.78	9.75e-3	32/42 (76.19%)	HLA-DRB1;HLA-DQB1;TNF;...
Mitophagy	-1.81	8.64e-3	56/68 (82.35%)	ATG5;NBR1;MITF;...
Other glycan degradation	-1.83	6.28e-3	13/18 (72.22%)	AGA;GLB1;HEXA;...
Lysosome	-1.83	6.91e-3	115/128 (89.84%)	AP3B1;DNASE2;AP1G1;...
Allograft rejection	-1.84	6.40e-3	32/38 (84.21%)	HLA-DRB1;HLA-DQB1;TNF;...
Type I diabetes mellitus	-1.85	5.76e-3	38/43 (88.37%)	HLA-DRB1;HLA-DQB1;TNF;...
Proteasome	-1.91	3.29e-3	44/46 (95.65%)	PSMD14;POMP;PSMC3;...
Collecting duct acid secretion	-1.98	0.00e+0	22/27 (81.48%)	ATP6V1C1;ATP6V1E1;ATP6V1F;...
Synaptic vesicle cycle	-1.99	0.00e+0	63/78 (80.77%)	SLC6A9;TCIRG1;DNM2;...
Phagosome	-2.05	0.00e+0	118/152 (77.63%)	ATP6V1G1;DYNC1I2;M6PR;...
Vibrio cholerae infection	-2.10	0.00e+0	44/50 (88%)	TCIRG1;PDIA4;ATP6V0D1;...
Terpenoid backbone biosynthesis	-2.10	0.00e+0	18/22 (81.82%)	GGPS1;IDI1;HMGCR;...
Steroid biosynthesis	-2.15	0.00e+0	19/20 (95%)	CYP27B1;SC5D;NSDHL;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	6.66uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼