Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMAKSMX)

Drug Name
Camicinal Drug Info
Synonyms 962040
Cross-matching ID
PubChem CID
15984937
ChEBI ID
CHEMBL489095
CAS Number
CAS 923565-21-3
TTD Drug ID
D05UYQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Parkinson disease 2.15 0.00e+0 176/249 (70.68%) GPR37;PSMA6;GNAS;...
Oxidative phosphorylation 2.08 0.00e+0 93/133 (69.92%) COX5B;NDUFB5;NDUFA7;...
Nitrogen metabolism 1.97 0.00e+0 16/17 (94.12%) CA2;CA12;GLUL;...
Proximal tubule bicarbonate reclamation 1.97 0.00e+0 21/23 (91.3%) CA2;SLC4A4;GLUD2;...
Cardiac muscle contraction 1.90 8.59e-3 64/87 (73.56%) COX5B;TPM4;TNNC1;...
Huntington disease 1.81 1.43e-2 233/306 (76.14%) PSMA6;COX5B;CYCS;...
Riboflavin metabolism 1.79 1.60e-2 7/8 (87.5%) BLVRB;ACP5;ENPP1;...
Proteasome 1.77 2.04e-2 44/46 (95.65%) PSMA6;PSMA3;PSME1;...
Ribosome 1.76 1.81e-2 113/158 (71.52%) MRPL15;RSL24D1;MRPS7;...
Peroxisome 1.76 1.72e-2 72/82 (87.8%) FAR2;PEX2;IDH2;...
Diabetic cardiomyopathy 1.75 1.95e-2 162/203 (79.8%) CD36;COX5B;PLN;...
Metabolism of xenobiotics by cytochrome P450 1.73 2.00e-2 49/77 (63.64%) ADH5;ADH1C;GSTO1;...
Pathways of neurodegeneration 1.70 3.44e-2 354/475 (74.53%) GPR37;MAP2K6;PSMA6;...
PPAR signaling pathway 1.67 4.48e-2 66/74 (89.19%) CD36;FABP5;PCK1;...
Porphyrin and chlorophyll metabolism 1.66 4.87e-2 23/43 (53.49%) BLVRB;UGT2A3;UGT2B17;...
Type II diabetes mellitus -1.91 5.88e-3 42/46 (91.3%) SOCS3;ADIPOQ;ABCC8;...
Notch signaling pathway -1.91 1.18e-2 49/59 (83.05%) CREBBP;HDAC1;HES1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H