General Information of Drug (ID: DMAO04B)

Drug Name
CEP-32496 Drug Info
Synonyms AB-024; B-RAF kinase inhibitors (melanoma), Ambit/Cephalon
Cross-matching ID
PubChem CID
56846693
ChEBI ID
CHEMBL2029988
CAS Number
CAS 1188910-76-0
TTD Drug ID
D04MXN
VARIDT Drug ID
DR00774

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Dopaminergic synapse 2.02 1.25e-2 115/132 (87.12%) CREB1;GNB2;GNAS;...
Endocrine and other factor-regulated calcium reabsorpti... 2.01 6.23e-3 49/53 (92.45%) DNM1;GNAS;PRKCA;...
Inositol phosphate metabolism 1.97 8.31e-3 66/73 (90.41%) IMPA2;PLCE1;CDIPT;...
Circadian entrainment 1.91 2.80e-2 85/97 (87.63%) CREB1;GNB2;GNAS;...
Histidine metabolism 1.86 2.74e-2 16/22 (72.73%) ALDH2;MAOA;HNMT;...
Gastric acid secretion 1.86 2.49e-2 63/76 (82.89%) GNAS;KCNJ15;PRKCA;...
Cholinergic synapse 1.85 2.14e-2 99/113 (87.61%) CREB1;GNB2;PRKCA;...
Insulin secretion 1.81 2.65e-2 75/86 (87.21%) SNAP25;CREB1;TRPM4;...
Vibrio cholerae infection 1.80 2.77e-2 44/50 (88%) ATP6V0E2;GNAS;PRKCA;...
Pentose phosphate pathway 1.80 2.99e-2 25/30 (83.33%) PGLS;PFKM;GPI;...
Lysosome 1.77 3.51e-2 115/128 (89.84%) GALC;ACP2;TPP1;...
Valine, leucine and isoleucine degradation 1.76 3.74e-2 42/48 (87.5%) ALDH2;ALDH6A1;DLD;...
Glutamatergic synapse 1.76 3.64e-2 97/114 (85.09%) GNB2;GNAS;PRKCA;...
Serotonergic synapse 1.76 3.56e-2 97/114 (85.09%) ALOX5;GNB2;GNAS;...
Leishmaniasis 1.74 3.57e-2 67/77 (87.01%) MARCKSL1;HLA-DPB1;TLR4;...
Propanoate metabolism 1.74 3.35e-2 30/34 (88.24%) SUCLG2;ALDH6A1;DLD;...
Axon guidance 1.73 3.37e-2 151/182 (82.97%) EPHB2;CXCL12;SEMA5A;...
Phosphatidylinositol signaling system 1.72 3.32e-2 82/97 (84.54%) IMPA2;PLCE1;CDIPT;...
Amphetamine addiction 1.71 3.34e-2 57/69 (82.61%) CREB1;GNAS;PRKCA;...
Glucagon signaling pathway 1.68 3.92e-2 89/107 (83.18%) CREB1;PFKM;PYGL;...
Aldosterone-regulated sodium reabsorption 1.68 3.86e-2 34/37 (91.89%) PRKCA;ATP1B1;SCNN1A;...
Peroxisome 1.66 4.08e-2 72/82 (87.8%) GSTK1;PHYH;ECH1;...
Melanogenesis 1.66 4.01e-2 74/101 (73.27%) CREB1;FZD2;GNAS;...
Asthma 1.66 3.89e-2 25/31 (80.65%) HLA-DPB1;HLA-DRA;HLA-DPA1;...
Growth hormone synthesis, secretion and action 1.65 3.94e-2 108/119 (90.76%) CREB1;IRS2;GHR;...
Sulfur relay system 1.65 3.98e-2 5/8 (62.5%) TST;MPST
Sulfur metabolism 1.65 3.83e-2 9/10 (90%) TST;SELENBP1;MPST;...
Other glycan degradation 1.64 3.78e-2 13/18 (72.22%) FUCA1;MANBA;GLB1;...
Fc gamma R-mediated phagocytosis 1.64 3.91e-2 79/97 (81.44%) MARCKSL1;PLPP2;PRKCA;...
Cocaine addiction 1.63 4.02e-2 42/49 (85.71%) CREB1;GNAS;MAOA;...
NF-kappa B signaling pathway -1.65 3.85e-2 90/104 (86.54%) PIDD1;BCL2L1;VCAM1;...
Rheumatoid arthritis -1.72 1.34e-2 78/93 (83.87%) ATP6V1G1;ANGPT1;TEK;...
Epithelial cell signaling in Helicobacter pylori infect... -1.75 1.10e-2 62/70 (88.57%) CDC42;NFKBIA;NFKB1;...
Lipid and atherosclerosis -1.78 9.37e-3 190/215 (88.37%) HSPA5;LDLR;ICAM1;...
Fluid shear stress and atherosclerosis -1.80 5.45e-3 123/139 (88.49%) SUMO4;ITGAV;NFKB1;...
Prion disease -1.83 4.50e-3 209/273 (76.56%) PSMA7;ADRM1;ATP5F1C;...
TNF signaling pathway -1.90 8.33e-4 103/112 (91.96%) RIPK1;MAP2K3;LTA;...
Viral protein interaction with cytokine and cytokine re... -1.93 0.00e+0 84/100 (84%) IL2;TNFRSF10B;LTA;...
Spliceosome -1.97 0.00e+0 101/150 (67.33%) MAGOH;SNRNP27;PRPF38B;...
Ribosome -2.02 0.00e+0 113/158 (71.52%) MRPL24;RPSA;RPL21;...
RNA transport -2.02 0.00e+0 128/186 (68.82%) EIF1AX;RANBP2;MAGOH;...
Ribosome biogenesis in eukaryotes -2.07 0.00e+0 52/108 (48.15%) NOP10;GAR1;REXO5;...
Proteasome -2.08 0.00e+0 44/46 (95.65%) PSMC3;PSMD8;PSMA7;...
Legionellosis -2.22 0.00e+0 51/57 (89.47%) TNF;IL1B;IL18;...
IL-17 signaling pathway -2.29 0.00e+0 84/94 (89.36%) MUC5B;HSP90B1;S100A7;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H