Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMAO80I)

Drug Name
Pralatrexate Drug Info
Synonyms Folotyn (TN)
Cross-matching ID
PubChem CID
148121
ChEBI ID
CHEMBL1201746
CAS Number
CAS 146464-95-1
TTD Drug ID
D02LWU
VARIDT Drug ID
DR00041
INTEDE Drug ID
DR1320
ACDINA Drug ID
D01353

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Graft-versus-host disease 1.97 2.11e-2 32/42 (76.19%) HLA-B;IL1B;FAS;...
Other glycan degradation 1.93 2.11e-2 13/18 (72.22%) MAN2B2;MAN2C1;MANBA;...
p53 signaling pathway 1.92 1.41e-2 63/73 (86.3%) CDKN1A;DDB2;CCNG1;...
Arachidonic acid metabolism 1.90 1.32e-2 48/61 (78.69%) AKR1C3;GPX1;LTA4H;...
DNA replication 1.90 1.06e-2 34/36 (94.44%) LIG1;POLD4;RFC4;...
Metabolism of xenobiotics by cytochrome P450 1.87 1.58e-2 49/77 (63.64%) GSTM3;AKR7A2;GSTK1;...
Retinol metabolism 1.86 1.36e-2 41/68 (60.29%) ALDH1A3;ALDH1A1;CYP26B1;...
One carbon pool by folate 1.80 1.45e-2 15/20 (75%) SHMT2;TYMS;MTHFD2;...
Mismatch repair 1.80 1.29e-2 22/23 (95.65%) LIG1;POLD4;RFC4;...
Necroptosis 1.76 2.43e-2 113/159 (71.07%) TNFRSF10B;SLC25A6;IL1B;...
Type I diabetes mellitus 1.75 2.40e-2 38/43 (88.37%) HLA-B;IL1B;FAS;...
Malaria 1.75 2.29e-2 44/50 (88%) IL1B;CXCL8;MET;...
Mitophagy 1.75 2.19e-2 56/68 (82.35%) TP53;BCL2L1;OPTN;...
Glutathione metabolism 1.74 2.04e-2 43/57 (75.44%) GSTM3;GSTK1;GPX1;...
NF-kappa B signaling pathway 1.73 2.04e-2 90/104 (86.54%) PIDD1;BCL2L1;IL1B;...
Glycine, serine and threonine metabolism 1.73 1.98e-2 31/40 (77.5%) SHMT2;CBS;AMT;...
Th1 and Th2 cell differentiation 1.73 1.93e-2 80/92 (86.96%) LCK;NFKBIA;CD3D;...
Nucleotide excision repair 1.71 1.94e-2 40/47 (85.11%) DDB2;LIG1;POLD4;...
Allograft rejection 1.69 2.34e-2 32/38 (84.21%) HLA-B;FAS;PRF1;...
Ribosome 1.68 2.54e-2 113/158 (71.52%) RPS4Y1;RPL36;RPS27L;...
Thyroid cancer 1.66 3.47e-2 36/37 (97.3%) CDKN1A;DDB2;TP53;...
Drug metabolism 1.65 3.46e-2 78/151 (51.66%) GSTM3;IMPDH2;GSTK1;...
Fanconi anemia pathway 1.65 3.35e-2 36/54 (66.67%) FANCG;FANCI;RPA3;...
Basal cell carcinoma 1.63 4.49e-2 41/63 (65.08%) CDKN1A;DDB2;TP53;...
Spinocerebellar ataxia -1.67 3.98e-2 128/143 (89.51%) ATXN3;AFG3L2;PSMA5;...
Steroid biosynthesis -1.82 5.58e-3 19/20 (95%) FDFT1;CYP27B1;MSMO1;...
Terpenoid backbone biosynthesis -1.85 4.14e-3 18/22 (81.82%) DHDDS;MVD;FDPS;...
mRNA surveillance pathway -1.87 3.49e-3 71/98 (72.45%) NXT1;PELO;TARDBP;...
RNA transport -1.88 3.99e-3 128/186 (68.82%) EIF2B4;SUMO1;THOC2;...
Oocyte meiosis -1.92 3.10e-3 90/129 (69.77%) PPP2R1B;ADCY2;MAPK14;...
Protein processing in endoplasmic reticulum -2.08 1.86e-3 127/171 (74.27%) TRAF2;HSPA2;MBTPS1;...
Proteasome -2.12 0.00e+0 44/46 (95.65%) ADRM1;PSMB2;PSMB3;...
Spliceosome -2.13 0.00e+0 101/150 (67.33%) HSPA2;LSM3;THOC1;...
Ribosome biogenesis in eukaryotes -2.13 0.00e+0 52/108 (48.15%) NXT1;RRP7A;FCF1;...
Progesterone-mediated oocyte maturation -2.18 0.00e+0 75/100 (75%) ADCY2;GNAI2;RAF1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H