Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMAOJBX)

Drug Name
Tetrandrine Drug Info
Synonyms Tetrandrine, Millenia Hope; Tetrandrine, West Virginia University; Tranex-18
Cross-matching ID
PubChem CID
73078
ChEBI ID
CHEMBL49
CAS Number
CAS 518-34-3
TTD Drug ID
D0G4ES
INTEDE Drug ID
DR1570

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.45 0.00e+0 19/20 (95%) MSMO1;SQLE;DHCR7;...
Terpenoid backbone biosynthesis 2.37 0.00e+0 18/22 (81.82%) HMGCS1;ACAT2;IDI1;...
Biosynthesis of unsaturated fatty acids 2.22 0.00e+0 21/27 (77.78%) SCD;FADS1;FADS2;...
Lysosome 2.09 2.69e-3 115/128 (89.84%) LIPA;NEU1;NPC2;...
PPAR signaling pathway 1.95 2.80e-2 66/74 (89.19%) SCD;HMGCS1;FADS2;...
Butanoate metabolism 1.93 2.69e-2 23/28 (82.14%) HMGCS1;ACAT2;AACS
Vibrio cholerae infection 1.92 2.31e-2 44/50 (88%) SLC12A2;ERO1A;ATP6AP1;...
AMPK signaling pathway 1.90 2.29e-2 106/120 (88.33%) SCD;HMGCR;FASN;...
HIF-1 signaling pathway 1.89 2.27e-2 105/109 (96.33%) ALDOC;ENO2;HK2;...
Cholesterol metabolism 1.86 3.01e-2 44/50 (88%) LDLR;LIPA;NPC2;...
Amino sugar and nucleotide sugar metabolism 1.85 3.13e-2 38/48 (79.17%) GNPDA1;HK2;GNE;...
Mineral absorption 1.82 4.03e-2 48/60 (80%) HMOX1;TF;FTH1;...
Ferroptosis 1.80 4.80e-2 36/41 (87.8%) ACSL3;HMOX1;TF;...
Spliceosome -1.65 4.67e-2 101/150 (67.33%) SNU13;PRPF38B;PRPF8;...
p53 signaling pathway -1.71 3.35e-2 63/73 (86.3%) CDK6;CHEK2;BCL2L1;...
Cell cycle -1.76 2.33e-2 110/124 (88.71%) CCNH;PCNA;CDK6;...
RNA transport -1.78 2.28e-2 128/186 (68.82%) SENP2;NMD3;NUP54;...
Staphylococcus aureus infection -1.80 2.07e-2 72/95 (75.79%) SELP;C2;HLA-DQA1;...
RNA polymerase -1.86 8.86e-3 23/31 (74.19%) POLR3C;POLR3D;POLR2F;...
Ribosome biogenesis in eukaryotes -1.86 1.11e-2 52/108 (48.15%) NMD3;SNU13;NXF2;...
Intestinal immune network for IgA production -1.86 1.48e-2 38/48 (79.17%) HLA-DQA1;HLA-DOB;HLA-DMB;...
Ribosome -1.88 1.77e-2 113/158 (71.52%) RPS21;RPL35;FAU;...
Systemic lupus erythematosus -1.94 8.86e-3 45/135 (33.33%) HLA-DRA;C5;FCGR3B;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H