Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMARCKD)

Drug Name
5-METHOXYTRYPTAMINE Drug Info
Synonyms
5-METHOXYTRYPTAMINE; 608-07-1; 2-(5-Methoxy-1H-indol-3-yl)ethanamine; Mexamine; Methoxytryptamine; 3-(2-Aminoethyl)-5-methoxyindole; Mexamine base; 5MOT; 5-Mot; 1H-Indole-3-ethanamine, 5-methoxy-; 2-(5-Methoxyindol-3-yl)ethylamine; Meksamin; Meksamin (free base); 5-MeOT; O-Methylserotonin; 2-(5-Methoxy-1H-Indol-3-Yl)Ethan-1-Amine; NSC 56422; 5-MT; UNII-3VMW6141KC; INDOLE, 3-(2-AMINOETHYL)-5-METHOXY-; 5-methoxy-1H-indole-3-ethanamine; EINECS 210-153-7; Lopac-M-6628; 5-Methoxytryptamine, 97%; BRN 0145587; CHEMBL8165; 3VMW6141KC
Cross-matching ID
PubChem CID
1833
ChEBI ID
CHEMBL8165
CAS Number
CAS 608-07-1
TTD Drug ID
D04AQE

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Proteasome 2.24 0.00e+0 44/46 (95.65%) PSMD6;PSMD2;PSMD14;...
Ribosome 2.09 3.28e-3 113/158 (71.52%) RPS4Y1;MRPS2;MRPL23;...
Oxidative phosphorylation 2.05 2.19e-3 93/133 (69.92%) PPA2;ATP5MG;ATP5MC2;...
Pyrimidine metabolism 1.88 4.92e-3 40/56 (71.43%) TYMS;RRM2;NME4;...
DNA replication 1.88 3.93e-3 34/36 (94.44%) PCNA;POLE2;MCM6;...
Spliceosome 1.87 4.37e-3 101/150 (67.33%) LSM6;SNRPG;HSPA8;...
Base excision repair 1.87 5.62e-3 29/33 (87.88%) PCNA;POLE2;POLD3;...
Amyotrophic lateral sclerosis 1.79 1.23e-2 267/364 (73.35%) BID;PSMD6;PSMD2;...
Ribosome biogenesis in eukaryotes 1.79 1.46e-2 52/108 (48.15%) NVL;NXT1;RAN;...
Cell cycle 1.74 1.97e-2 110/124 (88.71%) PCNA;WEE1;CDC25A;...
Asthma 1.67 3.28e-2 25/31 (80.65%) HLA-DOB;CD40;HLA-DMB;...
Huntington disease 1.66 3.22e-2 233/306 (76.14%) PSMD6;PSMD2;PSMD14;...
Parkinson disease 1.65 3.18e-2 176/249 (70.68%) PSMD6;PSMD2;PSMD14;...
Mismatch repair 1.64 3.47e-2 22/23 (95.65%) PCNA;SSBP1;POLD3;...
RNA transport 1.61 4.72e-2 128/186 (68.82%) EIF4E2;EIF1AY;EIF3F;...
Fat digestion and absorption -1.67 4.60e-2 35/43 (81.4%) LIPF;PNLIPRP1;APOB;...
GABAergic synapse -1.68 4.34e-2 76/89 (85.39%) GABRA2;SLC6A13;GPHN;...
Renin-angiotensin system -1.69 4.59e-2 20/23 (86.96%) KLK1;AGT;ACE2;...
Aldosterone synthesis and secretion -1.69 4.63e-2 85/98 (86.73%) CALML4;CALML5;HSD3B2;...
Carbohydrate digestion and absorption -1.69 4.94e-2 37/47 (78.72%) AKT2;PIK3CA;PIK3CD;...
Glycine, serine and threonine metabolism -1.70 4.82e-2 31/40 (77.5%) GLDC;BPGM;ALAS1;...
Gastric acid secretion -1.71 4.58e-2 63/76 (82.89%) CALML3;CHRM3;KCNJ2;...
Insulin signaling pathway -1.72 4.74e-2 121/137 (88.32%) RHOQ;PIK3R3;RPS6KB1;...
Morphine addiction -1.76 4.63e-2 80/91 (87.91%) KCNJ3;GABRG2;GRK3;...
Proximal tubule bicarbonate reclamation -1.76 4.92e-2 21/23 (91.3%) GLUD2;ATP1A3;CA2;...
Cortisol synthesis and secretion -1.79 3.97e-2 58/65 (89.23%) CYP11B1;CREB3L1;NR0B1;...
Bacterial invasion of epithelial cells -1.85 2.12e-2 59/77 (76.62%) PIK3CA;PIK3CD;CDH1;...
Glycerolipid metabolism -1.86 2.65e-2 44/61 (72.13%) PNLIP;PNLIPRP2;MBOAT2;...
Insulin secretion -1.89 2.65e-2 75/86 (87.21%) GNA11;RAPGEF4;GCG;...
Relaxin signaling pathway -1.91 2.65e-2 114/129 (88.37%) INSL3;COL4A5;GNG12;...
Protein digestion and absorption -1.97 2.65e-2 78/103 (75.73%) ACE2;SLC7A7;PRSS1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H