Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMAS5BI)

Drug Name
anacardic acid Drug Info
Synonyms
Anacardic acid C15:3; CHEMBL464925; (8E,11E,14E)-Anacardic acid; NSC638512; 2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid; 18654-18-7; 2-hydroxy-6-[(8E,11E)-pentadeca-8,11,14-trienyl]benzoic acid; 2-hydroxy-6-[(8E,11E)-pentadeca-8,11,14-trien-1-yl]benzoic acid; 6-(8(Z),11(Z),14-Pentadecatrienyl)salicylic acid; 8,11,14-Anacardic acid; Anacardic acid IV; AC1NTUKB; 6-(8,11,14-Pentadecatrienyl)salicylic acid; Salicylic acid, 6-(8,11,14-pentadecatrienyl)-; SCHEMBL154720; GTPL6999; Benzoic acid, 2-hydroxy-6-(8,11,14-pentade
Cross-matching ID
PubChem CID
167551
ChEBI ID
CHEMBL33778
CAS Number
CAS 16611-84-0
TTD Drug ID
D0E6JS

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.50 0.00e+0 34/36 (94.44%) LIG1;MCM5;MCM2;...
Spliceosome 2.26 0.00e+0 101/150 (67.33%) LSM5;PUF60;SNRPD1;...
Ribosome 2.21 0.00e+0 113/158 (71.52%) RPL36;RPS5;MRPS16;...
Mismatch repair 2.09 1.83e-3 22/23 (95.65%) LIG1;RFC4;POLD1;...
Homologous recombination 1.97 5.85e-3 35/41 (85.37%) RAD51;RAD54B;BRCA1;...
Base excision repair 1.96 4.87e-3 29/33 (87.88%) LIG1;FEN1;POLE2;...
Parkinson disease 1.96 4.18e-3 176/249 (70.68%) GNAS;CYC1;TXN;...
Oxidative phosphorylation 1.96 3.66e-3 93/133 (69.92%) CYC1;ATP5MC1;ATP5MC2;...
Viral protein interaction with cytokine and cytokine re... 1.73 2.19e-2 84/100 (84%) CXCL5;CXCL14;CXCL8;...
Nucleotide excision repair 1.72 2.34e-2 40/47 (85.11%) LIG1;RFC4;POLE2;...
IL-17 signaling pathway 1.71 2.26e-2 84/94 (89.36%) CXCL5;CXCL8;CXCL1;...
Drug metabolism 1.71 2.38e-2 78/151 (51.66%) NME4;IMPDH2;NME1;...
Non-alcoholic fatty liver disease 1.69 2.36e-2 126/155 (81.29%) CXCL8;CYC1;LEPR;...
Biosynthesis of unsaturated fatty acids 1.66 3.19e-2 21/27 (77.78%) ELOVL2;SCD;HACD3;...
Thermogenesis 1.63 4.00e-2 173/232 (74.57%) GNAS;CYC1;ATP5MC1;...
Steroid hormone biosynthesis -1.70 4.98e-2 43/61 (70.49%) UGT2B4;HSD3B2;AKR1C4;...
Selenocompound metabolism -1.75 3.69e-2 11/17 (64.71%) CTH;PAPSS1;SEPHS2;...
Mitophagy -1.75 3.82e-2 56/68 (82.35%) ATF4;CSNK2A2;CALCOCO2;...
Phagosome -1.78 2.70e-2 118/152 (77.63%) FCGR2B;ATP6V0D1;THBS4;...
Inositol phosphate metabolism -1.78 3.09e-2 66/73 (90.41%) ITPKA;INPP5J;ITPK1;...
Phosphatidylinositol signaling system -1.78 3.39e-2 82/97 (84.54%) ITPK1;DGKB;MTMR6;...
Protein digestion and absorption -1.78 4.07e-2 78/103 (75.73%) ATP1A3;COL10A1;ATP1B1;...
Autophagy -1.83 2.86e-2 113/169 (66.86%) PPP2CB;PIK3CD;BECN1;...
Central carbon metabolism in cancer -1.83 3.82e-2 67/70 (95.71%) G6PD;TIGAR;PIK3CD;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H