Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMASGXJ)

• Drug Name: AMG 900 Drug Info
• Synonyms: AMG-900; AMG 900; 945595-80-2; AMG900; UNII-9R2G075611; N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine; 9R2G075611; N-(4-((3-(2-aminopyrimidin-4-yl)pyridin-2-yl)oxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine; N-[4-[3-(2-aminopyrimidin-4-yl)pyridin-2-yl]oxyphenyl]-4-(4-methylthiophen-2-yl)phthalazin-1-amine; N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen- 2-yl)phthalazin-1-amine; IVUGFMLRJOCGAS-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 24856041
  ChEBI ID: CHEMBL2140408
  CAS Number: CAS 945595-80-2
  TTD Drug ID: D0EJ3B

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Mineral absorption	2.23	0.00e+0	48/60 (80%)	MT1E;MT1H;MT1HL1;...
Complement and coagulation cascades	2.19	5.12e-3	76/85 (89.41%)	PLAT;CFD;SERPINB2;...
p53 signaling pathway	2.02	3.41e-3	63/73 (86.3%)	CDKN1A;FAS;SESN1;...
Small cell lung cancer	1.88	2.05e-2	90/92 (97.83%)	CDKN1A;FN1;LAMB1;...
Amoebiasis	1.80	3.89e-2	99/102 (97.06%)	FN1;IL1B;CXCL8;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲