Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMAT8CG)

Drug Name
Goserelin Drug Info
Synonyms AstraZeneca (TN); HS-2015; ZD-9393; Zoladex (TN)
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
5311128
ChEBI ID
CHEMBL5523
CAS Number
CAS 65807-02-5
TTD Drug ID
D00BCG
VARIDT Drug ID
DR00378

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Terpenoid backbone biosynthesis 1.95 2.53e-2 18/22 (81.82%) IDI1;GGPS1;FNTA;...
Valine, leucine and isoleucine degradation 1.91 1.27e-2 42/48 (87.5%) DLD;ABAT;ALDH7A1;...
Propanoate metabolism 1.90 8.45e-3 30/34 (88.24%) DLD;ABAT;PCCA;...
Renin-angiotensin system 1.87 1.27e-2 20/23 (86.96%) AGT;ACE2;MME;...
Tryptophan metabolism 1.78 4.05e-2 35/42 (83.33%) DLD;AOC1;KYNU;...
Lysine degradation 1.77 3.38e-2 51/63 (80.95%) DLD;BBOX1;PIPOX;...
Peroxisome 1.73 3.38e-2 72/82 (87.8%) GSTK1;PXMP2;AGPS;...
Spliceosome 1.72 3.38e-2 101/150 (67.33%) HSPA8;SNRPD1;LSM3;...
PPAR signaling pathway 1.71 3.85e-2 66/74 (89.19%) FABP5;SCD;SORBS1;...
Butanoate metabolism 1.66 4.99e-2 23/28 (82.14%) ABAT;ECHS1;BDH2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 2.5uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H