Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMAV2FM)

Drug Name
QX-314 Drug Info
Synonyms
QX 314; CHEBI:46937; 2-[(2,6-dimethylphenyl)amino]-N,N,N-triethyl-2-oxoethanaminium; 2-((2,6-Dimethylphenyl)amino)-N,N,N-triethyl-2-oxoethanaminium; Ethanaminium, 2-((2,6-dimethylphenyl)amino)-N,N,N-triethyl-2-oxo-; Tocris-1014; AC1Q5LWR; Lopac-L-5783; UPCMLD-DP014; AC1L1H0Q; SCHEMBL93854; Lopac0_000679; KBioGR_000191; BSPBio_001471; KBioSS_000191; GTPL2405; UPCMLD-DP014:001; CHEMBL1180496; C16H27N2O; KBio3_000382; KBio2_005327; KBio2_002759; KBio2_000191; KBio3_000381; QX314; Bio2_000671; Bio2_000191; ZINC2037285; CCG-204765
Therapeutic ClassAnalgesics
Cross-matching ID
PubChem CID
9884487
CAS Number
CAS 24003-58-5
TTD Drug ID
D0C4JX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Dilated cardiomyopathy 2.08 5.05e-3 86/96 (89.58%) TNNC1;TPM3;LMNA;...
Hypertrophic cardiomyopathy 1.95 5.05e-3 81/90 (90%) TNNC1;TPM3;LMNA;...
DNA replication 1.87 1.18e-2 34/36 (94.44%) RFC4;POLD4;POLD2;...
Homologous recombination 1.83 1.14e-2 35/41 (85.37%) BRCC3;BARD1;MUS81;...
Steroid biosynthesis 1.78 1.41e-2 19/20 (95%) DHCR24;SQLE;CYP51A1;...
Steroid hormone biosynthesis -1.66 4.80e-2 43/61 (70.49%) CYP1A2;HSD11B1;AKR1C4;...
Glycine, serine and threonine metabolism -1.66 4.99e-2 31/40 (77.5%) SDS;DLD;CBS;...
Valine, leucine and isoleucine degradation -1.67 4.79e-2 42/48 (87.5%) ECHS1;ALDH9A1;BCAT2;...
Ascorbate and aldarate metabolism -1.69 4.27e-2 15/30 (50%) ALDH7A1;ALDH1B1;AKR1A1;...
Ferroptosis -1.70 4.02e-2 36/41 (87.8%) PCBP2;GCLM;FTL;...
Autophagy -1.70 4.14e-2 113/169 (66.86%) GABARAPL2;ATG12;PIK3CA;...
Synaptic vesicle cycle -1.71 4.35e-2 63/78 (80.77%) ATP6V0A2;ATP6V0B;NSF;...
Tryptophan metabolism -1.71 4.50e-2 35/42 (83.33%) ECHS1;ALDH9A1;DLD;...
Arginine and proline metabolism -1.72 4.13e-2 39/50 (78%) SMOX;PYCR1;GOT1;...
Phagosome -1.73 3.96e-2 118/152 (77.63%) MARCO;ATP6V0A2;RAB5A;...
Metabolism of xenobiotics by cytochrome P450 -1.73 4.03e-2 49/77 (63.64%) CYP1A2;AKR7A3;GSTT2;...
Antigen processing and presentation -1.74 3.65e-2 60/78 (76.92%) NFYC;HSPA1A;CIITA;...
Vitamin digestion and absorption -1.76 3.11e-2 17/24 (70.83%) PNLIP;APOA1;LMBRD1;...
Folate biosynthesis -1.76 3.35e-2 23/26 (88.46%) ALPL;PAH;AKR1C3;...
Fatty acid degradation -1.76 3.62e-2 40/43 (93.02%) ECI2;ECHS1;ALDH9A1;...
Pantothenate and CoA biosynthesis -1.77 3.70e-2 14/21 (66.67%) ALDH1B1;DPYD;ALDH3A2;...
beta-Alanine metabolism -1.78 3.65e-2 25/30 (83.33%) ECHS1;ALDH9A1;DPYS;...
Thyroid hormone synthesis -1.83 2.18e-2 66/75 (88%) GPX1;SLC26A4;CREB3;...
Protein processing in endoplasmic reticulum -1.87 1.75e-2 127/171 (74.27%) SEL1L;SEC23A;EIF2AK2;...
D-Glutamine and D-glutamate metabolism -1.93 8.02e-3 5/5 (100%) DGLUCY;GLS2;GLUD2;...
Collecting duct acid secretion -1.96 7.01e-3 22/27 (81.48%) ATP6V0A2;SLC4A1;ATP6V0C;...
Alanine, aspartate and glutamate metabolism -1.96 8.42e-3 27/37 (72.97%) AGXT;GOT1;ASRGL1;...
Proximal tubule bicarbonate reclamation -1.98 7.01e-3 21/23 (91.3%) FXYD2;GLS2;ATP1B3;...
Arginine biosynthesis -2.00 4.68e-3 17/22 (77.27%) ASL;GLS2;GLUD2;...
Nitrogen metabolism -2.12 0.00e+0 16/17 (94.12%) GLUD2;CA12;GLUL;...
Mineral absorption -2.20 0.00e+0 48/60 (80%) FXYD2;VDR;ATP1B3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 15uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H