Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMAWI4M)

Drug Name
SC-514 Drug Info
Synonyms
354812-17-2; Sc 514; SC514; 4-Amino-[2,3'-bithiophene]-5-carboxamide; 3-amino-5-(thiophen-3-yl)thiophene-2-carboxamide; CHEMBL193093; IKK-2 Inhibitor, SC-514; 5-(Thien-3-yl)-3-aminothiophene-2-carboxamide; C9H8N2OS2; GK 01140; Curator_000007; 4-Amino-[2,3-bithiophene]-5-carboxamide; BiomolKI_000076; BiomolKI2_000080; AC1MD9M6; 3-amino-5-thiophen-3-ylthiophene-2-carboxamide; Oprea1_591652; SCHEMBL4082097; KS-00000XLB; CHEBI:92464; ZINC81904; CTK8E9458; BDBM26098; SYN5231
Cross-matching ID
PubChem CID
2807869
ChEBI ID
CHEMBL193093
CAS Number
CAS 354812-17-2
TTD Drug ID
D0T6VA

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Pyrimidine metabolism 2.00 1.59e-2 40/56 (71.43%) TYMP;CANT1;ENTPD1;...
Starch and sucrose metabolism -1.71 3.79e-2 25/36 (69.44%) AGL;PYGB;G6PC2;...
Tyrosine metabolism -1.73 2.84e-2 30/36 (83.33%) DBH;ALDH3B1;HPD;...
Tryptophan metabolism -1.74 2.78e-2 35/42 (83.33%) DHTKD1;EHHADH;IDO1;...
Glycerolipid metabolism -1.81 1.06e-2 44/61 (72.13%) LIPC;PNPLA3;PLPP2;...
Renin-angiotensin system -1.86 6.52e-3 20/23 (86.96%) PREP;CTSG;THOP1;...
Citrate cycle (TCA cycle) -1.91 2.94e-3 30/30 (100%) DLST;SDHD;CS;...
Lysosome -1.91 3.35e-3 115/128 (89.84%) CTSF;AP1G1;ATP6V0A1;...
Nicotinate and nicotinamide metabolism -1.95 1.96e-3 25/35 (71.43%) SIRT2;NMRK2;NT5C2;...
Proximal tubule bicarbonate reclamation -1.96 2.35e-3 21/23 (91.3%) PCK2;CA4;MDH1;...
Valine, leucine and isoleucine degradation -2.05 0.00e+0 42/48 (87.5%) HSD17B10;BCKDHA;ACADM;...
Steroid hormone biosynthesis -2.05 0.00e+0 43/61 (70.49%) HSD17B12;HSD3B2;UGT2A3;...
Ferroptosis -2.23 0.00e+0 36/41 (87.8%) TF;GCLC;TP53;...
Steroid biosynthesis -2.29 0.00e+0 19/20 (95%) TM7SF2;EBP;FDFT1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H