Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMAX9C3)

Drug Name
AZD3463 Drug Info
Synonyms AZD-3463; CS-1382; HY-15609; KB-154896
Cross-matching ID
PubChem CID
56599293
ChEBI ID
CHEMBL4203266
CAS Number
CAS 1356962-20-3
TTD Drug ID
D0O7LU

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Hypertrophic cardiomyopathy -1.79 2.92e-2 81/90 (90%) ATP2A2;PRKAB1;PRKAG1;...
Melanoma -1.80 3.90e-2 68/72 (94.44%) AKT1;FGF2;RB1;...
Tight junction -1.82 2.34e-2 130/169 (76.92%) PRKAB1;TJP3;PRKAG1;...
Proteasome -2.17 0.00e+0 44/46 (95.65%) PSMC2;PSMD3;PSMC5;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H