Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMAY7H4)

Drug Name
Valdecoxib Drug Info
Synonyms
Bextra; COX; Kudeq; Valdyn; Pfizer brand of valdecoxib; Valdecoxib [USAN]; SC 65872; ND-0214; SC-65872; YM-974; Valdecoxib (USAN/INN); P-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide; Benzenesulfonamide, 4-(5-methyl-3-phenyl-4-isoxazolyl)-(9CI); 4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide; 4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide; 4-(5-methyl-3-phenyl-4-isoxazolyl) benzenesulfonamide; 4-(5-methyl-3-phenyl-isoxazol-4-yl)benzenesulfonamide; 4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide; 4-(Methyl-3-phenyl-isoxazol-4-yl)-benzenesulfonamide
Therapeutic ClassAntiinflammatory Agents
Cross-matching ID
PubChem CID
119607
ChEBI ID
CHEMBL865
CAS Number
CAS 181695-72-7
TTD Drug ID
D0L6DA
VARIDT Drug ID
DR01196
INTEDE Drug ID
DR1666

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycine, serine and threonine metabolism 2.11 0.00e+0 31/40 (77.5%) PSAT1;PHGDH;SHMT2;...
One carbon pool by folate 2.05 0.00e+0 15/20 (75%) MTHFD2;SHMT2;TYMS;...
Fanconi anemia pathway 1.88 1.51e-2 36/54 (66.67%) RPA2;REV3L;MLH1;...
Citrate cycle (TCA cycle) 1.86 1.42e-2 30/30 (100%) PCK2;IDH2;CS;...
Glyoxylate and dicarboxylate metabolism 1.85 1.36e-2 23/30 (76.67%) SHMT2;AMT;GLDC;...
DNA replication 1.79 2.64e-2 34/36 (94.44%) MCM3;RPA2;RFC5;...
Insulin secretion 1.75 3.40e-2 75/86 (87.21%) CREB3L2;KCNN4;STX1A;...
RNA polymerase -1.71 4.37e-2 23/31 (74.19%) POLR2E;POLR3F;POLR3K;...
Cytokine-cytokine receptor interaction -1.72 4.02e-2 246/295 (83.39%) TNFRSF1B;TNFSF15;CSF2;...
Viral protein interaction with cytokine and cytokine re... -1.76 3.50e-2 84/100 (84%) CCL27;TNFRSF10D;CX3CR1;...
Legionellosis -1.95 2.91e-3 51/57 (89.47%) TLR2;NFKB2;MYD88;...
Steroid biosynthesis -2.07 4.37e-3 19/20 (95%) FDFT1;HSD17B7;SOAT1;...
Staphylococcus aureus infection -2.11 0.00e+0 72/95 (75.79%) ITGAM;FCGR2B;FCGR2A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 200uM 6H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 200uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 200uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 200uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 200uM 6H
MDST8 CVCL_1400 Homo sapiens 200uM 6H
NCI-H508 CVCL_1561 Homo sapiens 200uM 6H
SNU-1040 CVCL_5001 Homo sapiens 200uM 6H
SNU-C4 CVCL_5008 Homo sapiens 200uM 6H
SNU-C5 CVCL_5009 Homo sapiens 200uM 6H
SW480 CVCL_0546 Homo sapiens 200uM 6H
SW620 CVCL_0547 Homo sapiens 200uM 6H
SW948 CVCL_0550 Homo sapiens 200uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 200uM 6H
HT115 CVCL_1294 Homo sapiens 200uM 6H
RKO CVCL_0504 Homo sapiens 200uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 200uM 6H
SNG-M CVCL_1707 Homo sapiens 200uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 200uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 200uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 200uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 200uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 200uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 200uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 200uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 200uM 6H
T3M-10 CVCL_1729 Homo sapiens 200uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 200uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 200uM 6H
HCC515 CVCL_5134 Homo sapiens 200uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 200uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 200uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 200uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 200uM 6H
OV7 CVCL_1623 Homo sapiens 200uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 200uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 200uM 6H
RMUG-S CVCL_1666 Homo sapiens 200uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 200uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 200uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 200uM 6H
PL-21 CVCL_2161 Homo sapiens 200uM 6H
SKM-1 CVCL_0010 Homo sapiens 200uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 200uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 200uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM - 200uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 200uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 200uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 200uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 200uM 6H