Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMAYTWN)

Drug Name
FR122047 Drug Info
Synonyms FR 122047; FR 122047 hydrochloride; FR-122047
Cross-matching ID
PubChem CID
196840
CAS Number
CAS 130717-51-0
TTD Drug ID
D09CMJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.55 0.00e+0 19/20 (95%) MSMO1;SQLE;CYP51A1;...
Valine, leucine and isoleucine degradation 2.17 0.00e+0 42/48 (87.5%) HMGCS1;ACAT2;DLD;...
Glyoxylate and dicarboxylate metabolism 2.03 2.71e-3 23/30 (76.67%) ACAT2;DLD;PCCB;...
Tryptophan metabolism 1.93 1.42e-2 35/42 (83.33%) CYP1B1;ACAT2;DLD;...
Glycine, serine and threonine metabolism 1.92 1.30e-2 31/40 (77.5%) DLD;GATM;MAOB;...
Butanoate metabolism 1.89 1.36e-2 23/28 (82.14%) HMGCS1;ACAT2;ALDH5A1;...
Terpenoid backbone biosynthesis 1.88 1.51e-2 18/22 (81.82%) HMGCS1;FDPS;ACAT2;...
Biosynthesis of unsaturated fatty acids 1.81 1.93e-2 21/27 (77.78%) FADS2;FADS1;SCD;...
Maturity onset diabetes of the young 1.71 4.07e-2 21/26 (80.77%) HHEX;SLC2A2;NKX2-2;...
Sulfur metabolism 1.71 3.74e-2 9/10 (90%) TST;SUOX;PAPSS2;...
Synthesis and degradation of ketone bodies 1.71 3.40e-2 9/10 (90%) HMGCS1;ACAT2;HMGCS2;...
TNF signaling pathway -1.82 2.81e-2 103/112 (91.96%) TNFRSF1B;RIPK1;IL18R1;...
Galactose metabolism -1.98 6.02e-3 26/31 (83.87%) HK1;B4GALT1;SI;...
Viral protein interaction with cytokine and cytokine re... -2.02 1.20e-2 84/100 (84%) CXCL11;IL19;TNFRSF1B;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H