Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMB0NVQ)

Drug Name
Steroid derivative 1 Drug Info
Synonyms PMID26882240-Compound-23
Cross-matching ID
PubChem CID
66414
ChEBI ID
CHEMBL299613
CAS Number
CAS 362-07-2
TTD Drug ID
D0E6VS

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Spliceosome 2.16 0.00e+0 101/150 (67.33%) LSM5;SNRPF;RBM25;...
Ribosome biogenesis in eukaryotes 2.11 0.00e+0 52/108 (48.15%) RPP38;RPP40;NXF3;...
Mineral absorption 1.93 7.57e-3 48/60 (80%) MT1E;MT1X;MT1G;...
RNA degradation 1.93 5.67e-3 53/79 (67.09%) LSM5;CNOT4;MPHOSPH6;...
Amoebiasis 1.87 1.13e-2 99/102 (97.06%) CXCL8;GNA11;CXCL3;...
Proteasome 1.85 1.89e-2 44/46 (95.65%) PSMD12;PSMD1;PSME4;...
Pantothenate and CoA biosynthesis -1.56 4.74e-2 14/21 (66.67%) BCAT2;DPYS;ALDH3A2;...
Nucleotide excision repair -1.58 4.60e-2 40/47 (85.11%) CUL4B;POLD1;GTF2H4;...
Tryptophan metabolism -1.61 3.66e-2 35/42 (83.33%) ALDH1B1;AOC1;EHHADH;...
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -1.61 3.76e-2 20/26 (76.92%) PIGV;PIGA;PIGZ;...
Cell cycle -1.62 3.61e-2 110/124 (88.71%) CDC25B;ANAPC13;PRKDC;...
Glycosaminoglycan degradation -1.62 3.38e-2 19/19 (100%) HYAL1;HPSE;HYAL2;...
One carbon pool by folate -1.65 2.98e-2 15/20 (75%) MTHFD2;FTCD;ALDH1L1;...
Folate biosynthesis -1.67 2.21e-2 23/26 (88.46%) DHFR;PAH;AKR1B1;...
beta-Alanine metabolism -1.69 2.07e-2 25/30 (83.33%) ALDH1B1;EHHADH;ALDH6A1;...
Histidine metabolism -1.70 2.05e-2 16/22 (72.73%) ALDH1B1;AOC1;MAOA;...
Oxidative phosphorylation -1.73 1.46e-2 93/133 (69.92%) NDUFB6;NDUFS8;ATP5MC3;...
Terpenoid backbone biosynthesis -1.74 1.36e-2 18/22 (81.82%) MVD;MVK;ACAT1;...
Pentose and glucuronate interconversions -1.74 1.39e-2 17/34 (50%) UGT2B28;UGP2;GUSB;...
Steroid hormone biosynthesis -1.75 1.37e-2 43/61 (70.49%) CYP11B2;HSD17B8;CYP17A1;...
Base excision repair -1.76 1.45e-2 29/33 (87.88%) POLD2;MUTYH;POLD4;...
Glycine, serine and threonine metabolism -1.81 6.89e-3 31/40 (77.5%) GCAT;BHMT;GAMT;...
Citrate cycle (TCA cycle) -1.82 6.15e-3 30/30 (100%) IDH3A;MDH2;ACO1;...
Ascorbate and aldarate metabolism -1.82 5.30e-3 15/30 (50%) UGDH;ALDH1B1;UGT2B28;...
Drug metabolism -1.85 3.59e-3 78/151 (51.66%) CMPK1;IMPDH2;ADH1A;...
Fatty acid degradation -1.90 1.57e-3 40/43 (93.02%) ADH5;ADH1C;ACADSB;...
Glutathione metabolism -1.94 8.61e-4 43/57 (75.44%) GSTK1;PRDX6;RRM1;...
Glyoxylate and dicarboxylate metabolism -1.95 9.57e-4 23/30 (76.67%) ACAT1;PCCB;MDH2;...
Pyruvate metabolism -1.96 1.08e-3 41/47 (87.23%) ME3;ADH1A;HAGH;...
Mismatch repair -1.99 1.23e-3 22/23 (95.65%) LIG1;RPA3;MSH2;...
Other glycan degradation -2.00 1.44e-3 13/18 (72.22%) GLB1;MANBA;HEXB;...
Valine, leucine and isoleucine degradation -2.02 0.00e+0 42/48 (87.5%) ALDH1B1;AACS;EHHADH;...
Glycolysis / Gluconeogenesis -2.09 0.00e+0 56/67 (83.58%) FBP1;ADH1A;MINPP1;...
Metabolism of xenobiotics by cytochrome P450 -2.10 0.00e+0 49/77 (63.64%) GSTM2;UGT2A3;CYP2B6;...
Steroid biosynthesis -2.35 0.00e+0 19/20 (95%) NSDHL;HSD17B7;LIPA;...
DNA replication -2.40 0.00e+0 34/36 (94.44%) RPA3;POLE;POLE2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H