Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMB19L8)

• Drug Name: Trihexyphenidyl Drug Info
• Synonyms: trihexyphenidyl; Benzhexol; Triphenidyl; Trihexyphenidyle; Parkinane retard; Benzhexolum; 144-11-6; Trihexyphenidylum; Sedrena (free base); Trihexifenidilo; Trihexyphenidyle [INN-French]; Trihexifenidilo [INN-Spanish]; Trihexyphenidylum [INN-Latin]; Artane; Trihexylphenizyl; Trihexylphenidyl; Trihexylphenidyle; Trihexyphenidyl [INN:BAN]; Trihexylphenedyl; HSDB 3196; EINECS 205-614-4; NSC 12268; 1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-; 1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol; BRN 0088959; Benzhexol; Trihexane; Trihexy; Artane Sequels; PMS Trihexyphenidyl; Apo-Trihex; Artane (TN); Trihexyphenidyl (INN); Apo-Trihex (TN); Apo-trihex (TN); SWR-0342SA
• Therapeutic Class: Antiparkinson Agents
• Cross-matching ID:
  PubChem CID: 5572
  ChEBI ID: CHEMBL1490
  CAS Number: CAS 144-11-6
  TTD Drug ID: D09GFL
  VARIDT Drug ID: DR00982
  INTEDE Drug ID: DR2309
  ACDINA Drug ID: D00704

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Protein digestion and absorption	2.01	1.10e-2	78/103 (75.73%)	COL1A1;COL5A2;COL1A2;...
Endocrine and other factor-regulated calcium reabsorpti...	1.96	1.10e-2	49/53 (92.45%)	CLTB;AP2A2;ATP1A1;...
Focal adhesion	1.93	7.34e-3	180/201 (89.55%)	COL1A1;FLNA;TNC;...
Parkinson disease	-1.71	3.81e-2	176/249 (70.68%)	ATF6;KIF5B;SLC6A3;...
Thermogenesis	-1.71	4.29e-2	173/232 (74.57%)	NDUFB11;COA7;COX4I1;...
Prion disease	-1.74	3.23e-2	209/273 (76.56%)	ADRM1;PSMD14;GSK3B;...
Mineral absorption	-1.78	2.86e-2	48/60 (80%)	ATP1A2;SLC30A1;ATP2B1;...
RNA polymerase	-1.80	3.25e-2	23/31 (74.19%)	POLR3F;POLR3G;POLR2C;...
Rheumatoid arthritis	-1.83	3.61e-2	78/93 (83.87%)	MMP1;HLA-DPA1;CTSK;...
Non-alcoholic fatty liver disease	-1.86	3.91e-2	126/155 (81.29%)	COX6C;NDUFA2;NDUFA1;...
Ribosome	-2.13	0.00e+0	113/158 (71.52%)	MRPL16;MRPL4;RPL15;...
Oxidative phosphorylation	-2.20	0.00e+0	93/133 (69.92%)	COX6C;NDUFA2;ATP4A;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼