Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMB1CZ8)

Drug Name
Guanfacine extended release Drug Info
Synonyms
Palmitoylethanolamide; Palmidrol; 544-31-0; N-(2-Hydroxyethyl)hexadecanamide; Impulsin; Palmitamide MEA; Hydroxyethylpalmitamide; N-palmitoylethanolamine; N-(2-Hydroxyethyl)palmitamide; Palmitic acid monoethanolamide; Palmitoyl-EA; Loramine P 256; Palmitoyl ethanolamide; Palmidrolum; palmitylethanolamide; HEXADECANAMIDE, N-(2-HYDROXYETHYL)-; Palmidrol [INN]; Palmidrolum [INN-Latin]; UNII-6R8T1UDM3V; Palmitinsaeure-beta-hydroxyethylamid; Monoethanolamine palmitic acid amide; NSC 23320; hexadecanoyl ethanolamide; Anandamide (16:0)
Cross-matching ID
PubChem CID
4671
ChEBI ID
CHEMBL417675
CAS Number
CAS 544-31-0
TTD Drug ID
D07ILQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome biogenesis in eukaryotes 2.16 0.00e+0 52/108 (48.15%) HEATR1;NVL;IMP3;...
Cell cycle 2.15 0.00e+0 110/124 (88.71%) CDC20;SMC1A;CDKN2C;...
One carbon pool by folate 2.10 0.00e+0 15/20 (75%) MTR;TYMS;MTHFD1;...
DNA replication 1.95 0.00e+0 34/36 (94.44%) RFC5;RFC3;PRIM1;...
Fanconi anemia pathway 1.84 1.97e-2 36/54 (66.67%) FANCI;REV1;HES1;...
RNA transport 1.78 2.15e-2 128/186 (68.82%) NUP210;EIF1AX;NUP107;...
RNA degradation 1.73 3.07e-2 53/79 (67.09%) LSM5;EXOSC4;EXOSC2;...
Spliceosome 1.68 4.07e-2 101/150 (67.33%) LSM5;PRPF4;SNRNP200;...
Alcoholism -1.66 3.50e-2 86/186 (46.24%) ATF2;TH;HDAC4;...
Long-term depression -1.67 3.03e-2 55/60 (91.67%) CRH;KRAS;GNA13;...
Gap junction -1.68 2.85e-2 72/88 (81.82%) CSNK1D;GNAI2;ADCY2;...
Retinol metabolism -1.69 2.81e-2 41/68 (60.29%) ADH1A;UGT2A3;CYP3A7;...
Platelet activation -1.69 2.92e-2 106/124 (85.48%) ITGA2;PLA2G4C;ARHGEF12;...
Mitophagy -1.69 2.87e-2 56/68 (82.35%) NRAS;GABARAPL2;ULK1;...
Circadian entrainment -1.70 2.94e-2 85/97 (87.63%) MAPK1;ITPR1;PER3;...
Bile secretion -1.70 2.83e-2 68/90 (75.56%) CA2;SLC22A1;ATP1B3;...
Epithelial cell signaling in Helicobacter pylori infect... -1.70 2.96e-2 62/70 (88.57%) NOD1;MAPK9;JUN;...
GnRH signaling pathway -1.70 2.98e-2 80/93 (86.02%) ADCY2;MAPK9;JUN;...
Cortisol synthesis and secretion -1.71 3.06e-2 58/65 (89.23%) SP1;ADCY2;CYP11B1;...
Synthesis and degradation of ketone bodies -1.72 2.87e-2 9/10 (90%) HMGCL;HMGCS2;HMGCS1
Long-term potentiation -1.72 2.81e-2 61/67 (91.04%) KRAS;MAPK1;RPS6KA3;...
IL-17 signaling pathway -1.75 2.35e-2 84/94 (89.36%) MAPK6;IKBKG;IL1B;...
Dopaminergic synapse -1.76 2.16e-2 115/132 (87.12%) CALY;GNAI2;MAPK9;...
Legionellosis -1.76 2.31e-2 51/57 (89.47%) IL1B;HSPA2;TNF;...
Retrograde endocannabinoid signaling -1.78 1.99e-2 118/148 (79.73%) GNAI2;ADCY2;MAPK9;...
Leishmaniasis -1.79 1.64e-2 67/77 (87.01%) HLA-DPA1;NFKBIA;HLA-DQB1;...
Vibrio cholerae infection -1.80 1.77e-2 44/50 (88%) KDELR2;SEC61B;ATP6V1E1;...
MAPK signaling pathway -1.81 1.93e-2 272/294 (92.52%) NLK;EFNA4;CACNB1;...
Complement and coagulation cascades -1.83 1.20e-2 76/85 (89.41%) CPB2;F8;F7;...
Amphetamine addiction -1.85 1.18e-2 57/69 (82.61%) JUN;ATF2;TH;...
Tyrosine metabolism -1.85 8.31e-3 30/36 (83.33%) DBH;ADH6;TPO;...
Glutamatergic synapse -1.89 5.70e-3 97/114 (85.09%) PLD1;PLA2G4C;SLC1A3;...
Serotonergic synapse -1.92 4.43e-3 97/114 (85.09%) PLA2G4C;ALOX5;CACNA1D;...
Pertussis -1.93 5.32e-3 64/76 (84.21%) IRF1;GNAI2;NOD1;...
Cocaine addiction -1.97 3.32e-3 42/49 (85.71%) GNAI2;JUN;ATF2;...
Synaptic vesicle cycle -2.01 0.00e+0 63/78 (80.77%) SLC17A6;SLC6A9;SLC6A4;...
Neutrophil extracellular trap formation -2.10 0.00e+0 101/189 (53.44%) NCF2;NFKB1;MAPK1;...
Steroid biosynthesis -2.12 0.00e+0 19/20 (95%) SOAT1;HSD17B7;EBP;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H