General Information of Drug (ID: DMB3R4Z)

Drug Name
SB 216641 Drug Info
Synonyms SB-216,641; SB-216641
Cross-matching ID
PubChem CID
3292447
ChEBI ID
CHEMBL20963
CAS Number
CAS 170230-39-4
TTD Drug ID
D0D9YW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.56 0.00e+0 19/20 (95%) MSMO1;SQLE;DHCR24;...
Biosynthesis of unsaturated fatty acids 2.34 0.00e+0 21/27 (77.78%) SCD;FADS1;FADS2;...
PPAR signaling pathway 2.27 0.00e+0 66/74 (89.19%) SCD;HMGCS1;ACSL3;...
Terpenoid backbone biosynthesis 2.07 2.68e-3 18/22 (81.82%) HMGCS1;IDI1;FDPS;...
Aldosterone synthesis and secretion 2.02 2.14e-3 85/98 (86.73%) LDLR;CALML5;ITPR3;...
Glutamatergic synapse 1.96 1.79e-3 97/114 (85.09%) ITPR3;SLC1A1;SLC38A1;...
Glycerolipid metabolism 1.95 1.53e-3 44/61 (72.13%) LPIN1;MGLL;PNPLA3;...
Fatty acid elongation 1.95 1.34e-3 19/27 (70.37%) ELOVL6;ELOVL5;TECR;...
GABAergic synapse 1.93 1.19e-3 76/89 (85.39%) GABBR1;SLC38A1;GNG11;...
Long-term potentiation 1.91 2.14e-3 61/67 (91.04%) CALML5;ITPR3;CAMK2B;...
Cardiac muscle contraction 1.91 1.95e-3 64/87 (73.56%) TPM2;ATP2A2;ATP1A2;...
Insulin secretion 1.89 1.79e-3 75/86 (87.21%) KCNN4;ITPR3;CAMK2B;...
Regulation of lipolysis in adipocytes 1.89 1.65e-3 52/55 (94.55%) MGLL;IRS2;NPY1R;...
Adrenergic signaling in cardiomyocytes 1.89 1.53e-3 130/150 (86.67%) TPM2;CALML5;ATP2A2;...
Dilated cardiomyopathy 1.87 2.14e-3 86/96 (89.58%) TPM2;ATP2A2;ITGB5;...
Circadian entrainment 1.85 3.35e-3 85/97 (87.63%) CALML5;ITPR3;CAMK2B;...
Cortisol synthesis and secretion 1.85 3.15e-3 58/65 (89.23%) LDLR;PBX1;ITPR3;...
Gastric acid secretion 1.85 3.57e-3 63/76 (82.89%) CALML5;ITPR3;CAMK2B;...
Salivary secretion 1.83 3.95e-3 76/93 (81.72%) CST3;CALML5;KCNN4;...
Adipocytokine signaling pathway 1.83 3.75e-3 64/69 (92.75%) ACSL3;IRS2;IRS1;...
GnRH secretion 1.83 3.57e-3 60/64 (93.75%) KCNN4;ITPR3;GABBR1;...
Fatty acid biosynthesis 1.80 7.31e-3 16/18 (88.89%) FASN;ACSL3;ACACA;...
Glucagon signaling pathway 1.79 7.46e-3 89/107 (83.18%) CALML5;PKM;ITPR3;...
Morphine addiction 1.78 7.59e-3 80/91 (87.91%) GABBR1;GNG11;GNAS;...
cGMP-PKG signaling pathway 1.77 9.43e-3 145/167 (86.83%) CALML5;ATP2A2;IRS2;...
AMPK signaling pathway 1.76 9.48e-3 106/120 (88.33%) SCD;FASN;HMGCR;...
Cushing syndrome 1.75 1.27e-2 125/155 (80.65%) LDLR;PBX1;ITPR3;...
Cholinergic synapse 1.74 1.38e-2 99/113 (87.61%) ITPR3;CAMK2B;PLCB4;...
Butanoate metabolism 1.73 1.66e-2 23/28 (82.14%) HMGCS1;ACAT2;AACS
Ovarian steroidogenesis 1.71 1.89e-2 41/51 (80.39%) LDLR;HSD17B7;GNAS;...
Th1 and Th2 cell differentiation -1.59 4.03e-2 80/92 (86.96%) NFKBIE;PRKCQ;CD3G;...
Hematopoietic cell lineage -1.60 3.87e-2 90/99 (90.91%) CD33;CD38;CD1A;...
Allograft rejection -1.61 3.59e-2 32/38 (84.21%) HLA-DRB1;HLA-DMB;HLA-DRA;...
NF-kappa B signaling pathway -1.61 3.55e-2 90/104 (86.54%) RIPK1;SYK;CFLAR;...
Nucleotide excision repair -1.65 2.50e-2 40/47 (85.11%) DDB1;POLE2;RFC3;...
Amyotrophic lateral sclerosis -1.65 2.61e-2 267/364 (73.35%) NUP85;COX8A;KLC2;...
Rheumatoid arthritis -1.66 2.52e-2 78/93 (83.87%) ATP6V1B1;FOS;CCL20;...
Ribosome -1.66 2.51e-2 113/158 (71.52%) RPL22;MRPS14;RPS3;...
RNA polymerase -1.66 2.63e-2 23/31 (74.19%) POLR3G;POLR2A;POLR2B;...
Staphylococcus aureus infection -1.67 2.43e-2 72/95 (75.79%) DEFA4;KRT13;FCGR2C;...
Oxidative phosphorylation -1.68 2.52e-2 93/133 (69.92%) ATP6V0A2;COX8A;NDUFC1;...
Parkinson disease -1.69 2.39e-2 176/249 (70.68%) COX8A;KLC2;PRKACB;...
Cytosolic DNA-sensing pathway -1.71 2.08e-2 52/63 (82.54%) IL18;POLR2F;POLR2H;...
RNA transport -1.71 1.97e-2 128/186 (68.82%) SUMO3;EIF2S1;DDX19A;...
Primary immunodeficiency -1.74 1.19e-2 33/38 (86.84%) ADA;CD8A;IL7R;...
Pertussis -1.75 1.28e-2 64/76 (84.21%) C4BPA;IRF8;CASP7;...
Mismatch repair -1.76 1.31e-2 22/23 (95.65%) MLH1;EXO1;RFC3;...
Spliceosome -1.78 1.26e-2 101/150 (67.33%) SF3B2;RBMX;HSPA6;...
Leishmaniasis -1.80 1.11e-2 67/77 (87.01%) TRAF6;CYBA;NFKBIA;...
Huntington disease -1.81 9.24e-3 233/306 (76.14%) COX8A;KLC2;DNAH9;...
Protein export -1.83 9.24e-3 17/23 (73.91%) SRP54;SPCS3;SEC61B;...
Asthma -1.83 1.06e-2 25/31 (80.65%) FCER1G;HLA-DRB1;HLA-DMB;...
Legionellosis -1.84 1.08e-2 51/57 (89.47%) NFKBIA;HSPD1;TLR2;...
Prion disease -1.87 7.39e-3 209/273 (76.56%) HSPA6;COX8A;KLC2;...
Intestinal immune network for IgA production -1.91 6.93e-3 38/48 (79.17%) HLA-DPB1;HLA-DOA;CD28;...
Systemic lupus erythematosus -2.00 0.00e+0 45/135 (33.33%) FCGR3B;CD86;SNRPD3;...
Proteasome -2.16 0.00e+0 44/46 (95.65%) PSMA5;PSMB6;PSMD7;...
Ribosome biogenesis in eukaryotes -2.19 0.00e+0 52/108 (48.15%) GNL2;POP4;NOP10;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 4uM - 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 4uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 4uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 4uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 4uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 4uM - 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 4uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 4uM - 10uM 6H, 24H