Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMB87M3)

Drug Name
AZD9668 Drug Info
Synonyms
Alvelestat; 848141-11-7; AZD9668; Alvelestat (AZD9668); AZD 9668; CHEMBL3617964; AZD-9668; KB-105160; Avelestat; 6-Methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-{[5-(methylsulfonyl)pyridin-2-yl]methyl}-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide; 6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-((5-(methylsulfonyl)pyridin-2-yl)methyl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide
Cross-matching ID
PubChem CID
46861623
ChEBI ID
CHEMBL3617964
CAS Number
CAS 848141-11-7
TTD Drug ID
D02PHE

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.10 0.00e+0 34/36 (94.44%) MCM6;MCM2;MCM3;...
Cell adhesion molecules 1.86 1.89e-2 118/148 (79.73%) HLA-DQA1;VCAM1;SELL;...
Staphylococcus aureus infection 1.85 1.26e-2 72/95 (75.79%) HLA-DQA1;KRT14;HLA-DPA1;...
Spliceosome 1.83 2.05e-2 101/150 (67.33%) SNRPE;LSM5;SNRPD2;...
Allograft rejection 1.82 1.64e-2 32/38 (84.21%) HLA-DQA1;HLA-DPA1;PRF1;...
Cell cycle 1.80 1.79e-2 110/124 (88.71%) MCM6;MCM2;TP53;...
Homologous recombination 1.79 1.89e-2 35/41 (85.37%) BARD1;ATM;RAD54B;...
Systemic lupus erythematosus 1.75 2.92e-2 45/135 (33.33%) HLA-DQA1;C7;HLA-DPA1;...
Antigen processing and presentation 1.74 2.59e-2 60/78 (76.92%) HLA-DQA1;HLA-DPA1;CD74;...
Pyrimidine metabolism 1.74 2.33e-2 40/56 (71.43%) RRM2;DCK;DUT;...
Asthma 1.74 2.12e-2 25/31 (80.65%) HLA-DQA1;HLA-DPA1;HLA-DPB1;...
Mismatch repair 1.70 2.89e-2 22/23 (95.65%) PCNA;RFC3;MSH6;...
Graft-versus-host disease 1.68 3.10e-2 32/42 (76.19%) HLA-DQA1;HLA-DPA1;PRF1;...
Ferroptosis -1.68 3.58e-2 36/41 (87.8%) SLC3A2;LPCAT3;ACSL5;...
Peroxisome -1.68 3.78e-2 72/82 (87.8%) ACOT8;ACSL1;PEX6;...
Glycerophospholipid metabolism -1.69 3.83e-2 71/98 (72.45%) ACHE;LPIN2;DGKI;...
Sulfur metabolism -1.71 2.99e-2 9/10 (90%) ETHE1;MPST;TST;...
AMPK signaling pathway -1.71 3.19e-2 106/120 (88.33%) CAB39L;PPP2R3C;PIK3CB;...
HIF-1 signaling pathway -1.71 3.21e-2 105/109 (96.33%) SERPINE1;ENO1;ENO3;...
Legionellosis -1.72 3.12e-2 51/57 (89.47%) CASP7;EEF1A2;BCL2L13;...
Lysosome -1.76 2.05e-2 115/128 (89.84%) HEXA;AP1S2;SCARB2;...
Rheumatoid arthritis -1.78 1.45e-2 78/93 (83.87%) ATP6V1D;CXCL5;CCL20;...
Fat digestion and absorption -1.81 1.01e-2 35/43 (81.4%) APOB;PNLIPRP2;CD36;...
Steroid hormone biosynthesis -1.81 9.66e-3 43/61 (70.49%) HSD11B1;UGT2B4;HSD17B8;...
Amino sugar and nucleotide sugar metabolism -1.82 1.09e-2 38/48 (79.17%) NPL;NANS;GALK1;...
Inositol phosphate metabolism -1.82 1.24e-2 66/73 (90.41%) OCRL;PI4K2A;PLCG1;...
Other glycan degradation -1.85 4.83e-3 13/18 (72.22%) HEXA;MAN2B2;MAN2B1;...
Fructose and mannose metabolism -1.86 5.80e-3 30/33 (90.91%) ALDOB;FPGT;MPI;...
Galactose metabolism -1.90 3.62e-3 26/31 (83.87%) LALBA;GAA;UGP2;...
Epithelial cell signaling in Helicobacter pylori infect... -2.06 0.00e+0 62/70 (88.57%) ATP6V1D;ATP6V1C1;ATP6AP1;...
Synaptic vesicle cycle -2.08 0.00e+0 63/78 (80.77%) SLC6A9;SLC6A3;RIMS1;...
Mineral absorption -2.29 0.00e+0 48/60 (80%) ATP1A2;SLC39A4;ATP2B1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H