Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMB8XZP)

Drug Name
SB-408124 Drug Info
Synonyms SB 408124; SB408124
Cross-matching ID
PubChem CID
4331799
ChEBI ID
CHEMBL1334465
CAS Number
CAS 288150-92-5
TTD Drug ID
D0J3PJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Estrogen signaling pathway 2.14 0.00e+0 119/137 (86.86%) KRT19;KRT14;GNAS;...
Phagosome -1.90 6.87e-3 118/152 (77.63%) MBL2;ATP6AP1;DYNC1I2;...
Complement and coagulation cascades -1.90 9.16e-3 76/85 (89.41%) C4BPB;C1QA;F7;...
Lysosome -1.93 1.03e-2 115/128 (89.84%) M6PR;SMPD1;CLTA;...
Oxidative phosphorylation -2.06 0.00e+0 93/133 (69.92%) NDUFB4;COX7A1;NDUFA1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.04uM - 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 6H, 24H