Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMB9Z4C)

Drug Name
PD-160170 Drug Info
Synonyms NCGC00092332-01; BRD-K12079898-001-01-8; 5-nitro-6-(2-propan-2-ylphenyl)sulfonyl-quinolin-8-amine
Cross-matching ID
PubChem CID
9820766
ChEBI ID
CHEMBL422942
CAS Number
CAS 181468-88-2
TTD Drug ID
D0Q3UL

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Folate biosynthesis 2.00 0.00e+0 23/26 (88.46%) AKR1C3;AKR1B10;AKR1B1;...
Ferroptosis 1.97 0.00e+0 36/41 (87.8%) HMOX1;GCLM;FTH1;...
Selenocompound metabolism 1.86 6.36e-3 11/17 (64.71%) TXNRD1;PAPSS1;SEPHS1;...
Arachidonic acid metabolism 1.86 4.77e-3 48/61 (78.69%) AKR1C3;CBR3;PLAAT3;...
Salivary secretion 1.86 5.72e-3 76/93 (81.72%) PLCB1;ATP1B3;STATH;...
Metabolism of xenobiotics by cytochrome P450 1.79 2.54e-2 49/77 (63.64%) CYP1B1;AKR1C1;GSTA1;...
Glutathione metabolism 1.70 4.91e-2 43/57 (75.44%) GSTA1;PGD;GPX2;...
Cytosolic DNA-sensing pathway -1.73 3.36e-2 52/63 (82.54%) IKBKB;CXCL10;IL33;...
Influenza A -1.75 2.48e-2 156/172 (90.7%) FAS;STAT2;IKBKB;...
Viral protein interaction with cytokine and cytokine re... -1.77 1.94e-2 84/100 (84%) PF4;CX3CL1;ACKR3;...
NOD-like receptor signaling pathway -1.79 1.91e-2 145/181 (80.11%) ANTXR1;DEFA5;PRKCD;...
Hedgehog signaling pathway -1.80 2.09e-2 43/56 (76.79%) GSK3B;SMURF1;CUL3;...
Hypertrophic cardiomyopathy -1.80 2.61e-2 81/90 (90%) EMD;MYL3;DAG1;...
Hepatitis C -1.86 2.43e-2 139/157 (88.54%) PIK3CD;RIPK1;EIF2AK2;...
Malaria -1.94 1.04e-2 44/50 (88%) MYD88;SDC1;TGFB1;...
RIG-I-like receptor signaling pathway -2.39 0.00e+0 64/70 (91.43%) RIPK1;CASP10;ATG12;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H