General Information of Drug (ID: DMBD4K3)

Drug Name
Selinexor Drug Info
Synonyms Xpovio; KPT 330; KPT-330; KPT-330(Selinexor); KPT330;Selinexor; 1393477-72-9; 31TZ62FO8F; CHEMBL3545185; SCHEMBL14678327; Selinexor; Selinexor (KPT-330); Selinexor [USAN:INN]; Tube706; UNII-31TZ62FO8F
Cross-matching ID
PubChem CID
71481097
ChEBI ID
CHEMBL3545185
CAS Number
CAS 1393477-72-9
TTD Drug ID
D00LNW
INTEDE Drug ID
DR1472
ACDINA Drug ID
D01420

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Cytosolic DNA-sensing pathway 1.93 4.58e-2 52/63 (82.54%) NFKBIA;CXCL10;CCL5;...
Allograft rejection 1.91 2.29e-2 32/38 (84.21%) HLA-B;HLA-F;FAS;...
Lysosome 1.91 1.53e-2 115/128 (89.84%) CTSA;GM2A;CTSL;...
Kaposi sarcoma-associated herpesvirus infection 1.90 1.15e-2 172/193 (89.12%) CDKN1A;TP53;NFKBIA;...
Autoimmune thyroid disease 1.89 9.16e-3 46/53 (86.79%) HLA-B;HLA-F;FAS;...
Herpes simplex virus 1 infection 1.88 9.55e-3 165/498 (33.13%) TP53;IFIH1;NFKBIA;...
Graft-versus-host disease 1.85 1.64e-2 32/42 (76.19%) HLA-B;HLA-F;FAS;...
Basal cell carcinoma 1.84 1.43e-2 41/63 (65.08%) CDKN1A;DDB2;TP53;...
Influenza A 1.83 1.27e-2 156/172 (90.7%) MX1;IFIH1;NFKBIA;...
Hepatitis C 1.83 1.15e-2 139/157 (88.54%) IFIT1;CDKN1A;MX1;...
Epstein-Barr virus infection 1.78 2.60e-2 189/202 (93.56%) ISG15;CDKN1A;DDB2;...
NOD-like receptor signaling pathway 1.74 2.86e-2 145/181 (80.11%) NFKBIA;OAS2;OAS1;...
Type I diabetes mellitus 1.73 2.82e-2 38/43 (88.37%) HLA-B;HLA-F;FAS;...
RIG-I-like receptor signaling pathway 1.73 3.11e-2 64/70 (91.43%) ISG15;IFIH1;NFKBIA;...
Viral myocarditis 1.69 3.97e-2 53/60 (88.33%) HLA-B;HLA-F;CD55;...
Measles 1.67 4.37e-2 133/139 (95.68%) MX1;TP53;IFIH1;...
Human papillomavirus infection 1.66 4.45e-2 284/331 (85.8%) ISG15;CDKN1A;MX1;...
Melanoma 1.65 4.58e-2 68/72 (94.44%) CDKN1A;DDB2;TP53;...
Small cell lung cancer 1.65 4.58e-2 90/92 (97.83%) CDKN1A;DDB2;TP53;...
Endometrial cancer 1.65 4.47e-2 56/58 (96.55%) CDKN1A;DDB2;TP53;...
Inflammatory bowel disease 1.64 4.96e-2 58/65 (89.23%) SMAD3;STAT1;STAT6;...
Arginine and proline metabolism -1.57 4.70e-2 39/50 (78%) GOT1;NOS2;MAOA;...
Non-homologous end-joining -1.57 4.62e-2 11/13 (84.62%) NHEJ1;XRCC5;DCLRE1C;...
Spinocerebellar ataxia -1.58 4.76e-2 128/143 (89.51%) PSMA4;PSMC5;GRIN2B;...
Porphyrin and chlorophyll metabolism -1.58 4.84e-2 23/43 (53.49%) CPOX;UGT2B17;ALAS2;...
Protein export -1.59 4.70e-2 17/23 (73.91%) SEC61G;SRP9;SPCS3;...
Base excision repair -1.60 4.33e-2 29/33 (87.88%) MBD4;POLE3;POLE;...
Neomycin, kanamycin and gentamicin biosynthesis -1.61 4.40e-2 5/5 (100%) HKDC1;HK1;HK2
N-Glycan biosynthesis -1.63 3.81e-2 38/50 (76%) DDOST;MOGS;DOLPP1;...
Glyoxylate and dicarboxylate metabolism -1.64 3.30e-2 23/30 (76.67%) PGP;ACO2;GLUL;...
Homologous recombination -1.66 2.96e-2 35/41 (85.37%) BLM;RPA3;TOPBP1;...
One carbon pool by folate -1.68 2.63e-2 15/20 (75%) GART;TYMS;ATIC;...
Amino sugar and nucleotide sugar metabolism -1.70 1.83e-2 38/48 (79.17%) AMDHD2;GFPT1;HKDC1;...
Galactose metabolism -1.71 1.63e-2 26/31 (83.87%) G6PC3;AKR1B1;B4GALT2;...
Arginine biosynthesis -1.74 1.46e-2 17/22 (77.27%) GLS2;ASL;GLUL;...
Cysteine and methionine metabolism -1.77 1.26e-2 43/50 (86%) AHCYL2;DNMT3A;MDH2;...
RNA transport -1.80 1.12e-2 128/186 (68.82%) RPP14;EIF2B1;EIF2S1;...
Spliceosome -1.84 9.29e-3 101/150 (67.33%) PRPF19;PQBP1;HNRNPA1;...
Mismatch repair -1.93 5.42e-3 22/23 (95.65%) RFC1;RPA3;LIG1;...
Protein processing in endoplasmic reticulum -2.03 1.63e-3 127/171 (74.27%) DERL2;MAN1A1;RPN2;...
Cell cycle -2.10 2.03e-3 110/124 (88.71%) CUL1;CCND2;BUB3;...
Oocyte meiosis -2.13 0.00e+0 90/129 (69.77%) PPP1CC;CAMK2B;ANAPC10;...
Progesterone-mediated oocyte maturation -2.27 0.00e+0 75/100 (75%) PIK3R2;FZR1;MAD1L1;...
DNA replication -2.43 0.00e+0 34/36 (94.44%) SSBP1;POLE3;POLE;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H