General Information of Drug (ID: DMBE5OF)

Drug Name
TAK165 Drug Info
Synonyms Mubritinib; TAK 165; Mubritinib (USAN/INN); 4-[[4-[4-(triazol-1-yl)butyl]phenoxy]methyl]-2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,3-oxazole
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
6444692
ChEBI ID
CHEMBL1614707
CAS Number
CAS 366017-09-6
TTD Drug ID
D0A9OV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
ECM-receptor interaction 2.36 0.00e+0 80/88 (90.91%) SPP1;THBS1;THBS2;...
Dilated cardiomyopathy 2.21 0.00e+0 86/96 (89.58%) ITGA4;TNNC1;DES;...
Hypertrophic cardiomyopathy 2.09 0.00e+0 81/90 (90%) ITGA4;TNNC1;DES;...
Focal adhesion 1.98 2.59e-3 180/201 (89.55%) SPP1;THBS1;THBS2;...
Sulfur metabolism 1.97 2.08e-3 9/10 (90%) PAPSS2;MPST;TST;...
Arrhythmogenic right ventricular cardiomyopathy 1.90 3.46e-3 70/77 (90.91%) ITGA4;DES;LAMA2;...
ABC transporters 1.83 1.04e-2 37/45 (82.22%) ABCA3;ABCC4;ABCC3;...
Protein digestion and absorption 1.82 1.56e-2 78/103 (75.73%) SLC3A1;COL10A1;COL14A1;...
Adipocytokine signaling pathway 1.76 2.88e-2 64/69 (92.75%) PRKCQ;CD36;IRS1;...
Adrenergic signaling in cardiomyocytes 1.75 3.22e-2 130/150 (86.67%) ADRB2;TNNC1;PLN;...
Insulin resistance 1.73 3.59e-2 96/108 (88.89%) PRKCQ;CD36;PRKCB;...
Cardiac muscle contraction 1.71 4.07e-2 64/87 (73.56%) TNNC1;MYL2;TPM3;...
Regulation of lipolysis in adipocytes 1.69 4.31e-2 52/55 (94.55%) ADRB2;FABP4;PLAAT3;...
Lipid and atherosclerosis -1.56 4.87e-2 190/215 (88.37%) VCAM1;PPP3CC;PLCB2;...
Drug metabolism -1.57 4.74e-2 78/151 (51.66%) ADH6;FMO1;GSTT2;...
Ferroptosis -1.58 4.50e-2 36/41 (87.8%) SLC39A8;GCLM;STEAP3;...
Staphylococcus aureus infection -1.58 4.42e-2 72/95 (75.79%) FCGR3B;HLA-DRB1;HLA-DPA1;...
Pathways of neurodegeneration -1.59 4.30e-2 354/475 (74.53%) BAK1;COX7A2L;DCTN5;...
Mineral absorption -1.60 4.13e-2 48/60 (80%) FTL;MT2A;ATOX1;...
Asthma -1.63 3.22e-2 25/31 (80.65%) FCER1A;HLA-DRB1;HLA-DPA1;...
Systemic lupus erythematosus -1.68 1.99e-2 45/135 (33.33%) CD80;C8B;ELANE;...
Graft-versus-host disease -1.68 2.04e-2 32/42 (76.19%) IL1B;CD80;PRF1;...
Spinocerebellar ataxia -1.69 2.09e-2 128/143 (89.51%) PSMA6;AKT3;ATG101;...
Oxidative phosphorylation -1.70 2.15e-2 93/133 (69.92%) COX17;ATP5F1C;NDUFA6;...
Protein export -1.70 2.26e-2 17/23 (73.91%) SPCS3;SRP14;SPCS1;...
IL-17 signaling pathway -1.73 1.80e-2 84/94 (89.36%) TRAF6;CCL17;CHUK;...
RNA transport -1.78 1.29e-2 128/186 (68.82%) EIF3E;EIF1;EIF5;...
DNA replication -1.85 5.37e-3 34/36 (94.44%) FEN1;PRIM1;RNASEH2B;...
Mismatch repair -1.86 5.73e-3 22/23 (95.65%) SSBP1;RFC2;RFC4;...
Antigen processing and presentation -1.87 2.73e-3 60/78 (76.92%) HSP90AB1;KLRC3;HLA-DRB1;...
Protein processing in endoplasmic reticulum -1.88 2.94e-3 127/171 (74.27%) SSR3;SKP1;CKAP4;...
Autoimmune thyroid disease -1.91 3.18e-3 46/53 (86.79%) FASLG;IFNA1;IL5;...
Ribosome biogenesis in eukaryotes -1.93 8.68e-4 52/108 (48.15%) GNL2;POP1;REXO5;...
Nucleotide excision repair -1.94 9.55e-4 40/47 (85.11%) CCNH;ERCC4;XPA;...
Allograft rejection -1.98 0.00e+0 32/38 (84.21%) FASLG;IL5;IL4;...
Type I diabetes mellitus -1.99 0.00e+0 38/43 (88.37%) IL1B;CD80;PRF1;...
Amyotrophic lateral sclerosis -2.06 0.00e+0 267/364 (73.35%) PSMC4;PPP3CC;DNAI2;...
Huntington disease -2.12 0.00e+0 233/306 (76.14%) TBPL1;KIF5A;DNAI1;...
Prion disease -2.14 0.00e+0 209/273 (76.56%) PSMC4;PPP3CC;COX5B;...
Parkinson disease -2.30 0.00e+0 176/249 (70.68%) ATP5F1C;PSMC5;NDUFA6;...
Proteasome -2.49 0.00e+0 44/46 (95.65%) PSMB4;PSME4;PSMC4;...
Spliceosome -2.50 0.00e+0 101/150 (67.33%) SRSF1;SYF2;CDC40;...
Ribosome -2.73 0.00e+0 113/158 (71.52%) RPS3;RPS2;RPLP0;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H