Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMBHMOX)

Drug Name
Palonosetron Drug Info
Synonyms Aloxi; Onicit; Palonosetron [INN]; Aloxi (TN); RS 25233-197; RS 25259-197; RS-25233-197; RS-25259-197; (S-(R*,R*))-2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one
Therapeutic ClassAntiemetics
Cross-matching ID
PubChem CID
6337614
ChEBI ID
CHEMBL1189679
CAS Number
CAS 135729-61-2
TTD Drug ID
D04FVU
VARIDT Drug ID
DR00394
INTEDE Drug ID
DR1232
ACDINA Drug ID
D00506

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Melanogenesis 1.93 4.61e-2 74/101 (73.27%) GNAS;TYRP1;DCT;...
Morphine addiction 1.86 3.69e-2 80/91 (87.91%) GNAS;PDE4B;PRKCA;...
RNA degradation 1.83 4.31e-2 53/79 (67.09%) LSM5;PARN;LSM8;...
Circadian entrainment 1.81 4.84e-2 85/97 (87.63%) GNAS;CACNA1D;PRKCA;...
Gap junction 1.76 4.77e-2 72/88 (81.82%) GNAS;TUBA1A;PRKCA;...
Homologous recombination 1.69 4.95e-2 35/41 (85.37%) RAD54B;TOPBP1;POLD4;...
Metabolism of xenobiotics by cytochrome P450 1.68 5.00e-2 49/77 (63.64%) AKR7A2;GSTA1;GSTM3;...
Bladder cancer -1.62 4.79e-2 40/41 (97.56%) MMP2;ARAF;MDM2;...
Staphylococcus aureus infection -1.63 4.81e-2 72/95 (75.79%) DEFB4A;C3;DEFA5;...
Hematopoietic cell lineage -1.64 4.42e-2 90/99 (90.91%) CD1A;IL1R1;CR1;...
Ferroptosis -1.65 4.16e-2 36/41 (87.8%) CP;GCLM;FTH1;...
Pertussis -1.66 3.75e-2 64/76 (84.21%) MYD88;IL23A;C1R;...
Apoptosis -1.66 3.90e-2 126/168 (75%) DDIT3;CASP8;IL3RA;...
Tuberculosis -1.67 3.75e-2 159/180 (88.33%) C3;HLA-DQB1;CYP27B1;...
IL-17 signaling pathway -1.69 2.97e-2 84/94 (89.36%) IL17RA;TRAF4;MAPK4;...
Chronic myeloid leukemia -1.73 1.80e-2 72/76 (94.74%) GADD45B;PTPN11;TGFB1;...
Leishmaniasis -1.73 1.93e-2 67/77 (87.01%) C3;HLA-DQB1;TRAF6;...
Viral protein interaction with cytokine and cytokine re... -1.74 1.74e-2 84/100 (84%) IL19;ACKR4;IL10;...
Phagosome -1.75 1.80e-2 118/152 (77.63%) HLA-B;STX12;ATP6V1B2;...
JAK-STAT signaling pathway -1.76 1.77e-2 146/162 (90.12%) PIAS4;IL23A;IL21R;...
NOD-like receptor signaling pathway -1.78 1.84e-2 145/181 (80.11%) SHARPIN;TXN;MEFV;...
Legionellosis -1.78 2.04e-2 51/57 (89.47%) SAR1B;NFKBIA;ITGB2;...
Cytosolic DNA-sensing pathway -1.81 1.48e-2 52/63 (82.54%) ADAR;IRF7;POLR3C;...
Cytokine-cytokine receptor interaction -1.82 1.54e-2 246/295 (83.39%) TNFSF14;IL6R;IL18;...
Rheumatoid arthritis -1.86 1.08e-2 78/93 (83.87%) ATP6V1B2;ATP6V1F;ATP6V1B1;...
Toll-like receptor signaling pathway -1.87 1.08e-2 94/104 (90.38%) TRAF6;CASP8;PIK3R1;...
ECM-receptor interaction -1.91 1.35e-2 80/88 (90.91%) CD47;COL9A2;ITGAV;...
Pantothenate and CoA biosynthesis -1.96 1.08e-2 14/21 (66.67%) DPYD;AASDHPPT;PANK3;...
TNF signaling pathway -2.02 1.62e-2 103/112 (91.96%) CXCL1;CASP8;PIK3R1;...
Measles -2.03 3.24e-2 133/139 (95.68%) TRAF6;CASP8;PIK3R1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H