Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMBHPDW)

Drug Name
Phenylbutyrate Drug Info
Synonyms
Benzenebutyric acid; Phenyl butanoate; Phenyl butyrate; HDInhib_000004; Butanoic acid, phenyl ester; Butyric acid, phenyl ester; FR-2080; Gamma-Phenylbutyric acid; Omega-Phenylbutanoic acid; GAMMA-PHENYL-BUTYRIC ACID; Butyric acid, 4-phenyl-(8CI); 1-Phenylbutyric acid; 4-PHENYL-BUTANOIC ACID; 4-PHENYLBUTYRIC ACID; 4-Phenylbutanoic acid; 4-phenylbutans; 4-phenylbutyrate
Cross-matching ID
PubChem CID
4775
ChEBI ID
CHEMBL1469
CAS Number
CAS 1821-12-1
TTD Drug ID
D0B7CH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cell cycle 2.06 0.00e+0 110/124 (88.71%) PLK1;MCM3;SKP2;...
RNA polymerase 2.01 0.00e+0 23/31 (74.19%) POLR3G;POLR3B;POLR2L;...
RNA transport 1.94 3.08e-3 128/186 (68.82%) NUP85;EEF1A2;PRMT5;...
Spliceosome 1.87 6.94e-3 101/150 (67.33%) HSPA8;PRPF4;HNRNPM;...
DNA replication 1.84 8.33e-3 34/36 (94.44%) MCM3;MCM2;POLE2;...
Ribosome biogenesis in eukaryotes 1.81 1.00e-2 52/108 (48.15%) NVL;EIF6;FBL;...
Fanconi anemia pathway 1.69 3.04e-2 36/54 (66.67%) REV1;REV3L;MLH1;...
Ribosome 1.68 3.24e-2 113/158 (71.52%) RPS4Y1;RPS26;MRPL12;...
RNA degradation 1.68 2.88e-2 53/79 (67.09%) BTG3;CNOT2;EXOSC8;...
Aminoacyl-tRNA biosynthesis 1.65 3.24e-2 15/66 (22.73%) IARS2;LARS2;HARS2;...
Yersinia infection -1.75 3.90e-2 120/137 (87.59%) IL1B;MAP3K7;TNF;...
Hematopoietic cell lineage -1.77 3.34e-2 90/99 (90.91%) CD3D;CD1A;CSF2RA;...
Mitophagy -1.83 1.50e-2 56/68 (82.35%) KRAS;BCL2L1;ULK1;...
Synaptic vesicle cycle -1.83 1.72e-2 63/78 (80.77%) SLC6A1;ATP6V0E2;SLC6A4;...
Rheumatoid arthritis -1.85 1.25e-2 78/93 (83.87%) IL1B;ATP6V0A2;TNF;...
T cell receptor signaling pathway -1.87 1.20e-2 93/104 (89.42%) MAP2K1;IL5;PAK5;...
Mineral absorption -1.88 1.13e-2 48/60 (80%) MT1H;SLC8A1;MT1F;...
Natural killer cell mediated cytotoxicity -1.91 1.00e-2 99/131 (75.57%) ITGB2;MAP2K2;FASLG;...
Lysosome -1.95 1.50e-2 115/128 (89.84%) CTSD;TCIRG1;GNPTAB;...
TNF signaling pathway -2.03 0.00e+0 103/112 (91.96%) CREB1;MAP2K7;PIK3R3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 20uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H