General Information of Drug (ID: DMBIO6E)

Drug Name
Meclinertant Drug Info
Synonyms
Reminertant; SR 48692; SR48692; SR-48692; 2-(((1-(7-Chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl)carbonyl)amino)tricyclo(3.3.1.1(sup 3,7))decane-2-carboxylic acid; 2-((1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl)carbonylamino)tricyclo(3.3.1.1.(3.7))decan-2-carboxylic acid;2-[[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazole-3-carbonyl]amino]adamantane-2-carboxylic acid
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
119192
ChEBI ID
CHEMBL506981
CAS Number
CAS 146362-70-1
TTD Drug ID
D0G0TS

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Type II diabetes mellitus 1.84 1.31e-1 42/46 (91.3%) PRKCD;ADIPOQ;CACNA1A;...
Arrhythmogenic right ventricular cardiomyopathy 1.77 1.84e-1 70/77 (90.91%) DSP;ATP2A3;ITGAV;...
Nicotine addiction 1.76 1.23e-1 32/40 (80%) GRIA2;GABRE;CACNA1A;...
Pyrimidine metabolism 1.72 1.42e-1 40/56 (71.43%) CANT1;CDA;ENTPD4;...
Cardiac muscle contraction 1.71 1.31e-1 64/87 (73.56%) ATP2A3;TNNC1;CACNB4;...
Dilated cardiomyopathy 1.64 1.76e-1 86/96 (89.58%) GNAS;ATP2A3;TNNC1;...
Taurine and hypotaurine metabolism 1.56 3.19e-1 8/11 (72.73%) ADO;CSAD;GGT5
Steroid biosynthesis 1.54 3.25e-1 19/20 (95%) LSS;SQLE;MSMO1;...
Base excision repair 1.53 2.99e-1 29/33 (87.88%) OGG1;PCNA;APEX2;...
Fc gamma R-mediated phagocytosis 1.53 2.88e-1 79/97 (81.44%) PRKCD;MARCKS;LIMK2;...
Central carbon metabolism in cancer 1.49 3.78e-1 67/70 (95.71%) SLC7A5;SLC2A1;SIRT3;...
Viral protein interaction with cytokine and cytokine re... 1.49 3.49e-1 84/100 (84%) CXCL9;CCL19;CXCL13;...
Hypertrophic cardiomyopathy 1.48 3.41e-1 81/90 (90%) ATP2A3;TNNC1;ITGAV;...
Diabetic cardiomyopathy 1.47 3.49e-1 162/203 (79.8%) PRKCD;PLCB4;SLC2A1;...
Insulin signaling pathway 1.40 5.26e-1 121/137 (88.32%) MKNK1;SHC1;PYGB;...
Insulin secretion 1.22 5.59e-1 75/86 (87.21%) GNAS;PLCB4;SLC2A1;...
Acute myeloid leukemia 1.22 5.63e-1 66/67 (98.51%) MPO;LEF1;CD14;...
Salmonella infection 1.21 5.55e-1 198/249 (79.52%) S100A10;LEF1;ARPC4;...
TGF-beta signaling pathway 1.21 5.55e-1 81/94 (86.17%) ID1;E2F5;INHBB;...
Protein digestion and absorption 1.18 5.58e-1 78/103 (75.73%) CPA3;KCNN4;COL11A1;...
Mannose type O-glycan biosynthesis 1.15 5.59e-1 14/23 (60.87%) FKTN;B3GAT1;POMGNT1;...
Glucagon signaling pathway 1.15 5.62e-1 89/107 (83.18%) GNAS;PLCB4;SLC2A1;...
Wnt signaling pathway 1.15 5.57e-1 124/166 (74.7%) PLCB4;LEF1;PRKCA;...
Relaxin signaling pathway 1.15 5.48e-1 114/129 (88.37%) GNAS;PLCB4;MMP9;...
ECM-receptor interaction 1.15 5.47e-1 80/88 (90.91%) ITGAV;LAMB3;ITGB4;...
Amoebiasis 1.14 5.56e-1 99/102 (97.06%) GNAS;PLCB4;LAMB3;...
Vasopressin-regulated water reabsorption 1.14 5.58e-1 40/44 (90.91%) GNAS;DYNC2H1;DYNC1I1;...
Osteoclast differentiation 1.14 5.59e-1 117/127 (92.13%) RELB;BLNK;SOCS1;...
NF-kappa B signaling pathway 1.14 5.55e-1 90/104 (86.54%) RELB;CCL19;BLNK;...
Gastric cancer 1.13 5.56e-1 122/149 (81.88%) SHC1;LEF1;FZD5;...
Drug metabolism -1.31 3.49e-1 78/151 (51.66%) FMO2;FMO4;IMPDH2;...
TNF signaling pathway -1.31 3.46e-1 103/112 (91.96%) FADD;MAP2K3;ATF4;...
Fluid shear stress and atherosclerosis -1.34 3.49e-1 123/139 (88.49%) CAV2;JUN;FOS;...
Folate biosynthesis -1.35 3.23e-1 23/26 (88.46%) AKR1B1;PTS;AKR1C3;...
Viral carcinogenesis -1.37 3.11e-1 149/203 (73.4%) UBE3A;HNRNPK;HLA-A;...
Glycine, serine and threonine metabolism -1.37 3.13e-1 31/40 (77.5%) BHMT;PSAT1;AGXT;...
Staphylococcus aureus infection -1.38 3.11e-1 72/95 (75.79%) FCGR3B;CFD;KRT38;...
Citrate cycle (TCA cycle) -1.38 3.22e-1 30/30 (100%) IDH2;DLST;OGDHL;...
Metabolism of xenobiotics by cytochrome P450 -1.39 3.17e-1 49/77 (63.64%) CYP2A6;GSTM5;ADH1B;...
Cholesterol metabolism -1.39 3.22e-1 44/50 (88%) APOC3;VDAC2;SOAT1;...
Protein export -1.39 3.32e-1 17/23 (73.91%) SRPRB;SEC61B;SRP72;...
Epithelial cell signaling in Helicobacter pylori infect... -1.39 3.44e-1 62/70 (88.57%) PTPRZ1;MAPK8;ATP6V0A2;...
Tyrosine metabolism -1.40 3.47e-1 30/36 (83.33%) TYRP1;ADH1B;MAOA;...
Steroid hormone biosynthesis -1.42 3.39e-1 43/61 (70.49%) HSD17B6;CYP11B2;HSD17B12;...
Mineral absorption -1.46 2.83e-1 48/60 (80%) SLC31A1;MT1G;ATP1A1;...
Phagosome -1.48 2.53e-1 118/152 (77.63%) TUBB;FCGR3B;STX18;...
Antigen processing and presentation -1.49 2.42e-1 60/78 (76.92%) CREB1;CD74;CTSS;...
Legionellosis -1.50 2.44e-1 51/57 (89.47%) TNF;IL6;SAR1A;...
Autoimmune thyroid disease -1.50 2.60e-1 46/53 (86.79%) HLA-A;CGA;HLA-DRA;...
Rheumatoid arthritis -1.51 2.57e-1 78/93 (83.87%) CXCL12;ANGPT1;HLA-DPB1;...
Kaposi sarcoma-associated herpesvirus infection -1.52 2.67e-1 172/193 (89.12%) RCAN1;HLA-A;IFNB1;...
Lysosome -1.57 1.90e-1 115/128 (89.84%) CTSZ;AP3S2;M6PR;...
Graft-versus-host disease -1.57 1.96e-1 32/42 (76.19%) HLA-DPB1;IL1A;HLA-G;...
Type I diabetes mellitus -1.58 2.17e-1 38/43 (88.37%) HLA-A;HLA-DRA;HSPD1;...
Histidine metabolism -1.58 2.47e-1 16/22 (72.73%) MAOA;ASPA;ALDH2;...
Complement and coagulation cascades -1.59 2.76e-1 76/85 (89.41%) F2R;PROCR;CFD;...
Allograft rejection -1.69 1.49e-1 32/38 (84.21%) HLA-G;HLA-E;HLA-C;...
Pertussis -1.76 9.09e-2 64/76 (84.21%) GNAI3;TNF;C5;...
Viral myocarditis -1.78 1.28e-1 53/60 (88.33%) LAMA2;FYN;SGCB;...
Retinol metabolism -1.80 2.04e-1 41/68 (60.29%) HSD17B6;DHRS9;CYP2A6;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H