Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMBJU2G)

Drug Name
SAR-260093 Drug Info
Cross-matching ID
PubChem CID
25025505
ChEBI ID
CHEMBL3260505
CAS Number
CAS 1037792-44-1
TTD Drug ID
D07QHF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycolysis / Gluconeogenesis 2.06 0.00e+0 56/67 (83.58%) PCK1;GPI;ENO2;...
Mineral absorption 1.97 9.72e-3 48/60 (80%) MT1F;MT1E;MT1HL1;...
DNA replication 1.92 2.27e-2 34/36 (94.44%) LIG1;RNASEH2A;MCM5;...
Tyrosine metabolism 1.90 1.94e-2 30/36 (83.33%) MAOB;ADH1C;TYRP1;...
Spliceosome 1.82 2.72e-2 101/150 (67.33%) SRSF1;PUF60;HSPA1A;...
Phenylalanine metabolism 1.79 3.24e-2 14/17 (82.35%) MAOB;PAH;ALDH3A1;...
Homologous recombination 1.78 2.78e-2 35/41 (85.37%) BRCA1;BRCA2;BLM;...
Drug metabolism 1.78 2.43e-2 78/151 (51.66%) MAOB;IMPDH2;FMO2;...
Fanconi anemia pathway 1.78 2.16e-2 36/54 (66.67%) BRCA1;MLH1;BRCA2;...
Cell cycle 1.74 3.01e-2 110/124 (88.71%) CDC20;CDC25B;CHEK2;...
Non-homologous end-joining 1.70 4.42e-2 11/13 (84.62%) PRKDC;XRCC5;MRE11;...
ECM-receptor interaction 1.68 4.94e-2 80/88 (90.91%) TNC;COL6A1;SPP1;...
One carbon pool by folate 1.68 4.78e-2 15/20 (75%) DHFR;MTHFD2;ATIC;...
Legionellosis -1.75 4.72e-2 51/57 (89.47%) CASP3;IL6;NFKBIA;...
NF-kappa B signaling pathway -1.77 4.47e-2 90/104 (86.54%) NFKBIA;TNFAIP3;PRKCB;...
Pertussis -1.77 4.95e-2 64/76 (84.21%) CASP3;IL6;MAPK9;...
Toll-like receptor signaling pathway -1.80 4.39e-2 94/104 (90.38%) FADD;IL6;NFKBIA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H