Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMBK86L)

Drug Name
chaetocin Drug Info
Synonyms
Chaetocin; Chetocin; 28097-03-2; Chaetocin from Chaetomium minutum; BRN 5722505; AC1L4PPK; GTPL8388; SCHEMBL13662584; CHEBI:94977; MolPort-003-983-881; NSC745363; NSC-745363; LS-52961; Chaetocin from Chaetomium minutum, > J-016970; BRD-A85860691-001-01-4; BRD-A85860691-001-03-0; hydroxymethyl-(hydroxymethyl-methyl-dioxo-[ ]yl)-methyl-[ ]dione; [10b,10'b(11H,11'H)-Bi-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone, 2,2',3,3',5a,5'a,6,6'-octahydro-3,3'-bis(hydroxymethyl)-2,2'-dime
Cross-matching ID
PubChem CID
11657687
ChEBI ID
CHEMBL1089316
CAS Number
CAS 28097-03-2
TTD Drug ID
D04FNI

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Antigen processing and presentation 2.26 0.00e+0 60/78 (76.92%) HSPA1A;HSPA6;HSPA8;...
Legionellosis 2.21 0.00e+0 51/57 (89.47%) HSPA1A;HSPA6;HSPA8;...
Protein processing in endoplasmic reticulum 2.12 0.00e+0 127/171 (74.27%) HSPA1A;HSPA6;DNAJB1;...
Folate biosynthesis 2.08 4.74e-3 23/26 (88.46%) AKR1C3;AKR1B10;SPR;...
Ferroptosis 2.07 3.80e-3 36/41 (87.8%) HMOX1;GCLM;SLC7A11;...
Steroid hormone biosynthesis 2.06 4.74e-3 43/61 (70.49%) AKR1C1;AKR1C2;AKR1C3;...
Pentose phosphate pathway 1.99 6.78e-3 25/30 (83.33%) G6PD;PGD;TKT;...
Metabolism of xenobiotics by cytochrome P450 1.99 7.12e-3 49/77 (63.64%) AKR1C1;ALDH3A1;CBR3;...
Pentose and glucuronate interconversions 1.96 1.27e-2 17/34 (50%) AKR1B10;UGDH;AKR1B1;...
Glutathione metabolism 1.95 1.33e-2 43/57 (75.44%) GCLM;G6PD;ODC1;...
Proteasome 1.93 1.38e-2 44/46 (95.65%) PSMB9;PSMA4;PSMB10;...
Rheumatoid arthritis 1.87 1.98e-2 78/93 (83.87%) CXCL5;CXCL8;CXCL6;...
Porphyrin and chlorophyll metabolism 1.86 1.90e-2 23/43 (53.49%) HMOX1;UGT2B28;UGT2A3;...
DNA replication 1.85 1.97e-2 34/36 (94.44%) PRIM1;MCM5;RPA3;...
Primary bile acid biosynthesis 1.84 1.90e-2 15/17 (88.24%) SLC27A5;AKR1C4;AMACR;...
Retinol metabolism 1.81 2.13e-2 41/68 (60.29%) UGT2B28;UGT2A3;DHRS3;...
Prion disease 1.80 2.12e-2 209/273 (76.56%) HSPA1A;HSPA6;HSPA8;...
Drug metabolism 1.78 2.37e-2 78/151 (51.66%) ALDH3A1;RRM2;DUT;...
Bile secretion 1.76 2.60e-2 68/90 (75.56%) EPHX1;ABCG2;ABCC2;...
Homologous recombination 1.72 3.46e-2 35/41 (85.37%) RPA3;RPA2;BRCA1;...
Systemic lupus erythematosus 1.68 4.47e-2 45/135 (33.33%) C1QA;FCGR3B;C2;...
Complement and coagulation cascades 1.68 4.27e-2 76/85 (89.41%) CLU;THBD;SERPIND1;...
Oocyte meiosis 1.68 4.17e-2 90/129 (69.77%) PLK1;CDC20;PTTG1;...
Basal cell carcinoma -1.73 4.47e-2 41/63 (65.08%) BMP4;GLI1;BMP2;...
Hepatitis C -1.75 3.90e-2 139/157 (88.54%) CLDN5;CLDN10;RIPK1;...
Proteoglycans in cancer -1.78 3.59e-2 172/205 (83.9%) TLR4;PPP1R12A;ERBB3;...
Endometrial cancer -1.79 3.65e-2 56/58 (96.55%) GADD45A;EGFR;ILK;...
Aldosterone-regulated sodium reabsorption -1.86 1.60e-2 34/37 (91.89%) ATP1B1;NR3C2;PIK3CB;...
Mitophagy -1.88 1.70e-2 56/68 (82.35%) MAPK8;RHOT1;GABARAPL2;...
C-type lectin receptor signaling pathway -1.93 7.98e-3 93/104 (89.42%) PIK3CA;NFKB2;CHUK;...
ErbB signaling pathway -1.93 1.06e-2 79/85 (92.94%) SHC3;EGFR;CRKL;...
Neurotrophin signaling pathway -1.93 1.60e-2 107/119 (89.92%) PIK3CA;MAGED1;MAPK8;...
Chronic myeloid leukemia -1.97 0.00e+0 72/76 (94.74%) GADD45A;CTBP2;SHC3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 0.08uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 0.08uM 6H
HT-29 CVCL_0320 Homo sapiens 0.08uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 0.08uM 6H
MDST8 CVCL_1400 Homo sapiens 0.08uM 6H
NCI-H508 CVCL_1561 Homo sapiens 0.08uM 6H
SNU-1040 CVCL_5001 Homo sapiens 0.08uM 6H
SNU-C4 CVCL_5008 Homo sapiens 0.08uM 6H
SNU-C5 CVCL_5009 Homo sapiens 0.08uM 6H
SW480 CVCL_0546 Homo sapiens 0.08uM 6H
SW620 CVCL_0547 Homo sapiens 0.08uM 6H
SW948 CVCL_0550 Homo sapiens 0.08uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 0.08uM 6H
HT115 CVCL_1294 Homo sapiens 0.08uM 6H
RKO CVCL_0504 Homo sapiens 0.08uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.08uM 6H
SNG-M CVCL_1707 Homo sapiens 0.08uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 0.08uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.08uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.08uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 10uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 0.08uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 0.08uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 0.08uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 0.08uM 6H
T3M-10 CVCL_1729 Homo sapiens 0.08uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 0.08uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 0.08uM 6H
HCC515 CVCL_5134 Homo sapiens 0.08uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 0.08uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 0.08uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 0.08uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 0.08uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 0.08uM 6H
OV7 CVCL_1623 Homo sapiens 0.08uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 0.08uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 0.08uM 6H
RMUG-S CVCL_1666 Homo sapiens 0.08uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 0.08uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.08uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 0.08uM 6H
PL-21 CVCL_2161 Homo sapiens 0.08uM 6H
SKM-1 CVCL_0010 Homo sapiens 0.08uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 0.08uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.08uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.08uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.08uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 0.08uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 0.08uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.08uM 6H