Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMBKESW)

Drug Name
XL888 Drug Info
Synonyms
5-((R)-sec-Butylamino)-N1-(8-(5-(cyclopropanecarbonyl)pyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-yl)-2-methylterephthalamide; SCHEMBL2425587; CHEMBL2204502; MolPort-035-395-767; EX-A1668; s7122; AKOS027253610; NCGC00386261-01; HY-13313; KB-81507; SC-95577; CS-0003194; SW219489-1
Cross-matching ID
PubChem CID
57748689
ChEBI ID
CHEMBL2204502
TTD Drug ID
D0V9MR

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Nitrogen metabolism 2.11 0.00e+0 16/17 (94.12%) GLUL;CPS1;GLUD1;...
Protein processing in endoplasmic reticulum 1.85 1.33e-2 127/171 (74.27%) HSPA1A;HSPH1;HSPA8;...
Spliceosome 1.83 1.11e-2 101/150 (67.33%) HSPA1A;HSPA8;HSPA6;...
Herpes simplex virus 1 infection -1.65 3.61e-2 165/498 (33.13%) AKT1;TNFRSF14;TRAF3;...
Cocaine addiction -1.66 3.34e-2 42/49 (85.71%) GNAS;CREB5;ATF4;...
Allograft rejection -1.67 3.33e-2 32/38 (84.21%) HLA-DOB;HLA-DRB1;HLA-C;...
Epithelial cell signaling in Helicobacter pylori infect... -1.67 3.36e-2 62/70 (88.57%) CXCL1;ATP6V0A2;LYN;...
NOD-like receptor signaling pathway -1.67 3.49e-2 145/181 (80.11%) ITPR1;CASP1;TNFAIP3;...
Human cytomegalovirus infection -1.67 3.42e-2 201/225 (89.33%) HRAS;RIPK1;ADCY1;...
Phototransduction -1.69 2.89e-2 21/29 (72.41%) CALML3;CALML5
AGE-RAGE signaling pathway in diabetic complications -1.69 3.01e-2 97/100 (97%) NOX4;TGFB1;KRAS;...
Epstein-Barr virus infection -1.70 2.92e-2 189/202 (93.56%) CD247;PSMC3;PSMD3;...
Pyrimidine metabolism -1.70 2.82e-2 40/56 (71.43%) NME3;RRM2;DCTD;...
Kaposi sarcoma-associated herpesvirus infection -1.74 1.83e-2 172/193 (89.12%) ITPR1;GNG12;AKT1;...
Graft-versus-host disease -1.75 1.66e-2 32/42 (76.19%) HLA-DOB;HLA-DRB1;HLA-C;...
Malaria -1.75 1.75e-2 44/50 (88%) GYPC;ICAM1;TGFB1;...
C-type lectin receptor signaling pathway -1.75 1.78e-2 93/104 (89.42%) IL23A;BCL3;PAK1;...
Asthma -1.82 1.18e-2 25/31 (80.65%) HLA-DOB;HLA-DRB1;HLA-DPA1;...
Amphetamine addiction -1.82 1.09e-2 57/69 (82.61%) FOS;ARC;GNAS;...
Rheumatoid arthritis -1.84 8.99e-3 78/93 (83.87%) ICAM1;HLA-DOB;CCL20;...
Osteoclast differentiation -1.85 8.72e-3 117/127 (92.13%) LILRA2;TNFRSF1A;IFNAR2;...
Influenza A -1.87 9.44e-3 156/172 (90.7%) CASP1;AKT1;TRAF3;...
Base excision repair -1.90 6.87e-3 29/33 (87.88%) APEX1;POLD3;MUTYH;...
TGF-beta signaling pathway -1.90 5.04e-3 81/94 (86.17%) SMURF1;TGFB1;INHBB;...
Long-term potentiation -1.92 2.80e-3 61/67 (91.04%) HRAS;ADCY1;RPS6KA3;...
NF-kappa B signaling pathway -1.93 3.15e-3 90/104 (86.54%) TNFAIP3;TRAF3;TNFRSF1A;...
Homologous recombination -1.95 1.80e-3 35/41 (85.37%) BRIP1;RAD51B;RAD54L;...
TNF signaling pathway -2.01 0.00e+0 103/112 (91.96%) MAP3K5;IRF1;AKT1;...
Mismatch repair -2.04 0.00e+0 22/23 (95.65%) MLH1;POLD3;MSH6;...
Leishmaniasis -2.04 0.00e+0 67/77 (87.01%) HLA-DOB;FOS;HLA-DRB1;...
IL-17 signaling pathway -2.21 0.00e+0 84/94 (89.36%) TNFAIP3;CCL7;TRAF3;...
Fanconi anemia pathway -2.44 0.00e+0 36/54 (66.67%) FANCI;BRIP1;MLH1;...
DNA replication -2.60 0.00e+0 34/36 (94.44%) DNA2;POLD3;RPA2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 0.12uM - 10uM 24H
TC-32 CVCL_7141 Homo sapiens 0.12uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 0.12uM - 10uM 24H
YH-13 CVCL_1800 Homo sapiens 0.12uM - 10uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 0.12uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 0.12uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.12uM - 10uM 24H
T-47D CVCL_0553 Homo sapiens 0.12uM - 10uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.12uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GP2d CVCL_1234 Homo sapiens 0.12uM - 10uM 24H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
SNU-407 CVCL_5004 Homo sapiens 0.12uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.12uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.12uM - 10uM 24H
HEC-151 CVCL_2927 Homo sapiens 0.12uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.12uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.12uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 0.12uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 0.12uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 0.12uM - 10uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.12uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 0.12uM - 10uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.12uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
NCI-H1437 CVCL_1472 Homo sapiens 0.12uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 0.12uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 0.12uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 0.12uM - 10uM 24H
HCC1588 CVCL_1263 Homo sapiens 0.12uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 0.12uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 0.12uM - 10uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.12uM - 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H841 CVCL_1595 Homo sapiens 0.12uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 0.12uM - 10uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 0.12uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVK18 CVCL_1629 Homo sapiens 0.12uM - 10uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.12uM - 10uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.12uM - 10uM 24H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 0.12uM - 10uM 24H
OC 316 CVCL_1615 Homo sapiens 0.12uM - 10uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 0.12uM - 10uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.12uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.12uM - 10uM 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.12uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
IGR-37 CVCL_1303 Homo sapiens 0.12uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 0.12uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 0.12uM - 10uM 24H
SK-MEL-3 CVCL_0525 Homo sapiens 0.12uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.12uM - 10uM 24H
MKN45 CVCL_0434 Homo sapiens 0.12uM - 10uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.12uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 0.12uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 0.12uM - 10uM 24H