Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMBKJL1)

• Drug Name: Cloperastine Drug Info
• Synonyms: Cloperastine hydrochloride; 14984-68-0; Seki; Cloperastine HCl; Cloperastina cloridrato [Italian]; EINECS 239-067-8; 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride; 2-Piperidinoethyl p-chlorobenzhydryl ether hydrochloride; 1-(2-((p-Chloro-alpha-phenylbenzyl)oxy)ethyl)piperidine hydrochloride; 1-(2-(p-Cloro-alpha-fenilbenzilossi)etil)piperidina cloridrato [Italian]; DSSTox_RID_80863; DSSTox_CID_25413; DSSTox_GSID_45413; Q-200881; 4-Chlorobenzhydryl 2-(1-Piperidyl)ethyl Ether Hydrochloride
• Cross-matching ID:
  PubChem CID: 2805
  ChEBI ID: CHEMBL415087
  CAS Number: CAS 3703-76-2
  TTD Drug ID: D0O8IS

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Metabolism of xenobiotics by cytochrome P450	2.05	0.00e+0	49/77 (63.64%)	UGT2B28;CYP1B1;AKR1C1;...
Viral protein interaction with cytokine and cytokine re...	1.94	1.37e-2	84/100 (84%)	CXCL13;CCL19;IL6ST;...
Glycine, serine and threonine metabolism	1.86	2.13e-2	31/40 (77.5%)	DLD;CBS;GATM;...
Ascorbate and aldarate metabolism	1.82	3.43e-2	15/30 (50%)	UGT2B28;ALDH3A2;ALDH7A1;...
Pentose and glucuronate interconversions	1.81	3.11e-2	17/34 (50%)	UGT2B28;SORD;UGP2;...
Ribosome	-2.39	0.00e+0	113/158 (71.52%)	RPL30;RPS13;RPLP0;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼