Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMBL3VD)

Drug Name
PF-05212384 Drug Info
Synonyms
PKI-587; 1197160-78-3; Gedatolisib; PF-05212384; PKI587; PKI 587; 1-(4-(4-(Dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)urea; PF 05212384; UNII-96265TNH2R; PF-05212384 (PKI-587); CHEMBL592445; 96265TNH2R; N-[4-[[4-(Dimethylamino)-1-piperidinyl]carbonyl]phenyl]-N'-[4-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]phenyl]urea; Gedatolisib (PF-05212384, PKI-587); Urea, N-(4-((4-(dimethylamino)-1-piperidinyl)carbonyl)phenyl)-N'-(4-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)phenyl)-
Cross-matching ID
PubChem CID
44516953
ChEBI ID
CHEMBL592445
CAS Number
CAS 1197160-78-3
TTD Drug ID
D0D8JB

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Autoimmune thyroid disease 2.00 1.77e-2 46/53 (86.79%) HLA-DRA;HLA-DRB1;HLA-DPB1;...
Lysosome 1.96 1.32e-2 115/128 (89.84%) TPP1;LAPTM5;CTSD;...
Type I diabetes mellitus 1.90 1.77e-2 38/43 (88.37%) HLA-DRA;HLA-DRB1;HLA-DPB1;...
Th1 and Th2 cell differentiation 1.86 1.77e-2 80/92 (86.96%) HLA-DRA;HLA-DRB1;IL2RG;...
Notch signaling pathway 1.74 4.59e-2 49/59 (83.05%) NOTCH1;NOTCH3;ATXN1;...
Graft-versus-host disease 1.73 4.42e-2 32/42 (76.19%) HLA-DRA;HLA-DRB1;HLA-DPB1;...
Allograft rejection 1.70 4.67e-2 32/38 (84.21%) HLA-DRA;HLA-DRB1;HLA-DPB1;...
Asthma 1.69 4.30e-2 25/31 (80.65%) HLA-DRA;HLA-DRB1;HLA-DPB1;...
Ribosome 1.69 3.83e-2 113/158 (71.52%) RPL36;RPL26;RPL14;...
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 1.69 3.53e-2 20/26 (76.92%) PIGP;PIGV;PIGF;...
Inflammatory bowel disease 1.68 3.69e-2 58/65 (89.23%) HLA-DRA;HLA-DRB1;IL2RG;...
Hematopoietic cell lineage 1.66 4.27e-2 90/99 (90.91%) CD44;HLA-DRA;HLA-DRB1;...
Th17 cell differentiation 1.66 4.01e-2 95/107 (88.79%) HLA-DRA;HLA-DRB1;IL2RG;...
Intestinal immune network for IgA production 1.63 4.86e-2 38/48 (79.17%) HLA-DRA;HLA-DRB1;HLA-DPB1;...
Prion disease -1.66 3.19e-2 209/273 (76.56%) HSPA8;MAPK1;IL6;...
Protein processing in endoplasmic reticulum -1.69 2.63e-2 127/171 (74.27%) SEC61G;EIF2AK3;SEC61A1;...
Steroid hormone biosynthesis -1.70 2.44e-2 43/61 (70.49%) SRD5A1;STS;UGT2B28;...
Legionellosis -1.72 2.37e-2 51/57 (89.47%) HSPD1;HSPA8;IL6;...
Terpenoid backbone biosynthesis -1.79 1.19e-2 18/22 (81.82%) HMGCR;PCYOX1;DHDDS;...
Glycolysis / Gluconeogenesis -1.82 7.39e-3 56/67 (83.58%) HKDC1;GPI;LDHC;...
PPAR signaling pathway -1.87 6.05e-3 66/74 (89.19%) ACOX2;SCP2;PLTP;...
Fatty acid degradation -1.89 5.54e-3 40/43 (93.02%) ALDH9A1;ACADSB;HADH;...
Citrate cycle (TCA cycle) -1.90 4.93e-3 30/30 (100%) MDH2;ACO2;MDH1;...
Cysteine and methionine metabolism -1.91 2.77e-3 43/50 (86%) GSS;BCAT1;LDHC;...
Glycine, serine and threonine metabolism -1.92 3.17e-3 31/40 (77.5%) BPGM;AOC3;ALAS1;...
Pyruvate metabolism -1.93 3.69e-3 41/47 (87.23%) LDHC;MDH2;ALDH9A1;...
Fatty acid elongation -1.98 0.00e+0 19/27 (70.37%) HADH;ECHS1;HACD2;...
Glutathione metabolism -2.00 0.00e+0 43/57 (75.44%) GSTT1;GSR;GGCT;...
Proteasome -2.05 0.00e+0 44/46 (95.65%) PSMA2;PSMA6;PSME1;...
Steroid biosynthesis -2.24 0.00e+0 19/20 (95%) LIPA;FDFT1;SOAT1;...
Biosynthesis of unsaturated fatty acids -2.29 0.00e+0 21/27 (77.78%) HACD2;HACD3;ELOVL6;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 4H, 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 24H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 4H, 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 4H, 24H
Mantle cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MINO CVCL_4965 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H