Details of the Drug Pharmacogenomic Perturbation Atlas

Ulipristal Drug Info

Cross-matching ID

PubChem CID

13559281

CAS Number

CAS 159811-51-5

TTD Drug ID

D0V4WD

INTEDE Drug ID

DR1657

General Information of Drug (ID: DMBNI20)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Starch and sucrose metabolism	2.00	0.00e+0	25/36 (69.44%)	AGL;UGP2;HK2;...
Intestinal immune network for IgA production	1.95	0.00e+0	38/48 (79.17%)	CXCL12;HLA-DPA1;HLA-DQB1;...
ECM-receptor interaction	1.90	4.45e-3	80/88 (90.91%)	COL4A5;COL4A6;CD44;...
Hematopoietic cell lineage	1.89	6.67e-3	90/99 (90.91%)	CD44;HLA-DPA1;CD59;...
Graft-versus-host disease	1.88	8.01e-3	32/42 (76.19%)	HLA-DPA1;HLA-DQB1;HLA-DRB1;...
Antigen processing and presentation	1.86	6.67e-3	60/78 (76.92%)	CREB1;HLA-DPA1;HLA-DQB1;...
Th17 cell differentiation	1.83	9.53e-3	95/107 (88.79%)	IL2RG;HLA-DPA1;HLA-DQB1;...
Estrogen signaling pathway	1.81	1.00e-2	119/137 (86.86%)	KRT15;CREB1;GNAS;...
Viral myocarditis	1.80	1.04e-2	53/60 (88.33%)	HLA-DPA1;HLA-DQB1;HLA-DRB1;...
Th1 and Th2 cell differentiation	1.77	1.73e-2	80/92 (86.96%)	NOTCH2;IL2RG;HLA-DPA1;...
Phenylalanine metabolism	1.74	2.55e-2	14/17 (82.35%)	AOC3;GOT2;PAH;...
Allograft rejection	1.73	2.89e-2	32/38 (84.21%)	HLA-DPA1;HLA-DQB1;HLA-DRB1;...
Chemokine signaling pathway	1.73	2.67e-2	163/192 (84.9%)	CXCL13;CXCL9;CXCL12;...
Leishmaniasis	1.72	2.76e-2	67/77 (87.01%)	HLA-DPA1;HLA-DQB1;HLA-DRB1;...
Systemic lupus erythematosus	1.72	2.76e-2	45/135 (33.33%)	ACTN1;HLA-DPA1;HLA-DQB1;...
Parathyroid hormone synthesis, secretion and action	1.71	3.09e-2	98/106 (92.45%)	CREB1;GNAS;GNA13;...
Neomycin, kanamycin and gentamicin biosynthesis	1.71	2.90e-2	5/5 (100%)	HK2;HK3
Chagas disease	1.67	4.08e-2	93/102 (91.18%)	GNAS;PIK3CD;TGFB1;...
Glycolysis / Gluconeogenesis	1.65	4.71e-2	56/67 (83.58%)	ENO2;ALDH3A2;PFKM;...
Cortisol synthesis and secretion	1.64	4.80e-2	58/65 (89.23%)	CREB1;GNAS;GNAQ;...
Amino sugar and nucleotide sugar metabolism	1.64	4.96e-2	38/48 (79.17%)	UGP2;HK2;GPI;...
Staphylococcus aureus infection	1.63	4.97e-2	72/95 (75.79%)	KRT15;HLA-DPA1;KRT14;...
Human immunodeficiency virus 1 infection	1.62	4.91e-2	189/212 (89.15%)	APOBEC3B;PAK1;PIK3CD;...
Nitrogen metabolism	-1.83	2.24e-2	16/17 (94.12%)	GLUL;CA12;GLUD1;...
Mineral absorption	-1.87	1.84e-2	48/60 (80%)	MT1HL1;TF;FTH1;...
Oxidative phosphorylation	-2.01	3.45e-3	93/133 (69.92%)	NDUFS8;COX6A1;NDUFV1;...
Ribosome	-2.07	6.90e-3	113/158 (71.52%)	RPL34;RPS6;RPL21;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	0.12uM - 10uM	6H, 24H, 48H

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H, 48H

MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H, 48H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 2.22uM	24H