Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMBQCMU)

• Drug Name: EI1 Drug Info
• Synonyms: KB-145943
• Cross-matching ID:
  PubChem CID: 72199293
  ChEBI ID: CHEMBL3414574
  CAS Number: CAS 1418308-27-6
  TTD Drug ID: D02CIT

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Mucin type O-glycan biosynthesis	1.90	3.38e-2	20/36 (55.56%)	GALNT12;GALNT1;ST6GALNAC2;...
Arginine biosynthesis	-1.73	4.69e-2	17/22 (77.27%)	OTC;GLUD1;GLS2;...
Fatty acid biosynthesis	-1.76	3.52e-2	16/18 (88.89%)	ACSBG1;ACACA;ACSL4;...
Porphyrin and chlorophyll metabolism	-1.86	1.34e-2	23/43 (53.49%)	FECH;COX10;CPOX;...
Retinol metabolism	-1.87	1.17e-2	41/68 (60.29%)	UGT2B4;CYP2C8;CYP3A7;...
Pentose and glucuronate interconversions	-1.87	1.41e-2	17/34 (50%)	UGT2B4;DCXR;UGDH;...
Mineral absorption	-1.91	1.17e-2	48/60 (80%)	MT1M;HMOX1;SLC26A3;...
Cholesterol metabolism	-1.95	7.82e-3	44/50 (88%)	APOC2;ANGPTL8;APOA2;...
Steroid biosynthesis	-2.10	0.00e+0	19/20 (95%)	FDFT1;TM7SF2;EBP;...
Complement and coagulation cascades	-2.32	0.00e+0	76/85 (89.41%)	C8B;C3;C6;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲