Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMBR01X)

• Drug Name: Brilinta Drug Info
• Synonyms: Ticagrelor; 274693-27-5; Brilique; AZD-6140; AZD6140; AZD 6140; AR-C126532XX; UNII-GLH0314RVC; [14C]-Ticagrelor; GLH0314RVC; CHEBI:68558; (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-DIFLUOROPHENYL)CYCLOPROPYL]AMINO]-5-(PROPYLTHIO)-3H-1,2,3-TRIAZOLO[4,5-D]PYRIMIDIN-3-YL]-5-(2-HYDROXYETHOXY)-1,2-CYCLOPENTANEDIOL; (1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol; Brilique; AR-C126532; Ticagrelor (USAN/INN); Brilinta/Brilique
• Cross-matching ID:
  PubChem CID: 9871419
  ChEBI ID: CHEMBL398435
  CAS Number: CAS 274693-27-5
  TTD Drug ID: D0WF7L
  VARIDT Drug ID: DR00077
  INTEDE Drug ID: DR1591
  ACDINA Drug ID: D00674

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Regulation of lipolysis in adipocytes	2.32	0.00e+0	52/55 (94.55%)	NPY1R;PLAAT3;INSR;...
Proximal tubule bicarbonate reclamation	-1.65	4.82e-2	21/23 (91.3%)	CA2;ATP1A1;GLUD1;...
Necroptosis	-1.66	4.42e-2	113/159 (71.07%)	BIRC2;IFNAR1;SQSTM1;...
Amyotrophic lateral sclerosis	-1.69	3.22e-2	267/364 (73.35%)	ATP5PO;PSMB3;PIK3C3;...
Huntington disease	-1.69	3.34e-2	233/306 (76.14%)	TGM2;POLR2H;ATP5PO;...
Steroid hormone biosynthesis	-1.72	2.69e-2	43/61 (70.49%)	CYP3A5;AKR1D1;CYP3A7;...
Complement and coagulation cascades	-1.72	2.89e-2	76/85 (89.41%)	PROC;CFD;C8B;...
Parkinson disease	-1.76	1.37e-2	176/249 (70.68%)	UCHL1;SLC6A3;ITPR1;...
Drug metabolism	-1.77	1.49e-2	78/151 (51.66%)	GSTA1;CYP3A5;CYP2A6;...
Glycolysis / Gluconeogenesis	-1.77	1.62e-2	56/67 (83.58%)	ADH6;GAPDH;PGM1;...
Pyruvate metabolism	-1.78	1.66e-2	41/47 (87.23%)	PCK2;PKM;ME2;...
Prion disease	-1.87	6.60e-3	209/273 (76.56%)	ITPR1;NDUFB2;NDUFS7;...
Primary bile acid biosynthesis	-1.89	4.46e-3	15/17 (88.24%)	SLC27A5;HSD17B4;AMACR;...
Mineral absorption	-1.95	0.00e+0	48/60 (80%)	ATP2B2;ATOX1;TF;...
Metabolism of xenobiotics by cytochrome P450	-1.99	0.00e+0	49/77 (63.64%)	GSTA1;CYP3A5;CYP2F1;...
Retinol metabolism	-2.04	0.00e+0	41/68 (60.29%)	CYP3A5;CYP2A6;ADH6;...
Oxidative phosphorylation	-2.15	0.00e+0	93/133 (69.92%)	NDUFB2;NDUFS7;ATP5MC2;...
Coronavirus disease	-2.23	0.00e+0	215/232 (92.67%)	RPS24;MAPK8;MAPK3;...
Tyrosine metabolism	-2.38	0.00e+0	30/36 (83.33%)	ADH6;TH;TYR;...
Ribosome	-2.40	0.00e+0	113/158 (71.52%)	RPL23A;RPS14;RPS10;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼