Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMBRVXY)

• Drug Name: SR144528 Drug Info
• Synonyms: SR 144528; SR144528; 192703-06-3; SR-144528; CHEMBL381791; 5-(4-Chloro-3-methylphenyl)-1-((4-methylphenyl)methyl)-N-(1,3,3-trimethylbicyclo(2.2.1)hept-2-yl)-1H-pyrazole-3-carboxamide (1S-endo)-; SR144,528; (1S-endo)-5-(4-Chloro-3-methylphenyl)-1-((4-methylphenyl)methyl)-N-(1,3,3-trimethylbicyclo(2.2.1)hept-2-yl)-1H-pyrazole-3-carboxamide; 5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-N-((1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)-1H-pyrazole-3-carboxamide; 1H-Pyrazole-3-carboxamide, 5-(4-chloro-3-methylphe
• Cross-matching ID:
  PubChem CID: 3081355
  ChEBI ID: CHEMBL381791
  CAS Number: CAS 192703-06-3
  TTD Drug ID: D0J8KW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Proteoglycans in cancer	1.91	2.20e-2	172/205 (83.9%)	ESR1;ERBB4;TIMP3;...
TGF-beta signaling pathway	1.86	2.20e-2	81/94 (86.17%)	THBS1;ID1;TGIF2;...
Sphingolipid metabolism	-1.76	4.40e-2	32/49 (65.31%)	GALC;GLA;SPTLC1;...
Porphyrin and chlorophyll metabolism	-1.78	3.46e-2	23/43 (53.49%)	UGT2A3;COX10;BLVRA;...
NF-kappa B signaling pathway	-1.79	4.10e-2	90/104 (86.54%)	IKBKB;LTB;BIRC2;...
Renin-angiotensin system	-1.80	4.55e-2	20/23 (86.96%)	CTSG;AGTR1;KLK2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H	Hide ▲