General Information of Drug (ID: DMBYDNE)

Drug Name
Managlinat dialanetil Drug Info
Synonyms
CS-917; GP-3034; MB-05032; MB-06322; MB-06633; MB-6322; R-132917; Type 2 diabetes therapeutic, Gensia/Sankyo; Type 2 diabetes therapeutic, SICOR/Sankyo; Diabetes therapeutics, Metabasis/Sanyko/Daiichi Sankyo; Purine nucleotide analogs, Gensia/Sankyo/Daiichi Sankyo; Purine nucleotide analogs, Metabasis/Sanyko/Daiichi Sankyo; Purine nucleotide analogs, SICOR/Sankyo/Daiichi Sankyo
Cross-matching ID
PubChem CID
73014123
TTD Drug ID
D0G2ZL

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Cortisol synthesis and secretion -1.62 4.82e-2 58/65 (89.23%) CREB3L2;ADCY9;PDE8B;...
AMPK signaling pathway -1.63 4.39e-2 106/120 (88.33%) PPP2R5B;PPP2R2B;STK11;...
Starch and sucrose metabolism -1.64 4.29e-2 25/36 (69.44%) TREH;HKDC1;MGAM;...
Arginine biosynthesis -1.64 4.44e-2 17/22 (77.27%) GOT2;GLS2;GLUD1;...
Th1 and Th2 cell differentiation -1.64 4.60e-2 80/92 (86.96%) MAML1;JAK1;STAT6;...
Amphetamine addiction -1.64 4.78e-2 57/69 (82.61%) SLC18A2;DRD1;GRIA2;...
Gastric acid secretion -1.66 4.20e-2 63/76 (82.89%) GNAI2;ATP4A;EZR;...
Nicotine addiction -1.66 4.25e-2 32/40 (80%) GABRB3;GABRA5;GABRA2;...
Pentose phosphate pathway -1.67 4.25e-2 25/30 (83.33%) ALDOA;PFKP;ALDOB;...
Parathyroid hormone synthesis, secretion and action -1.67 4.30e-2 98/106 (92.45%) RXRA;LRP5;GNAI2;...
Carbohydrate digestion and absorption -1.68 4.37e-2 37/47 (78.72%) AKT1;HK3;SI;...
Regulation of lipolysis in adipocytes -1.69 3.99e-2 52/55 (94.55%) PTGS2;ADRB2;NPPA;...
GnRH signaling pathway -1.70 4.20e-2 80/93 (86.02%) ADCY9;SRC;MMP2;...
Proximal tubule bicarbonate reclamation -1.71 4.19e-2 21/23 (91.3%) PCK2;PCK1;ATP1A2;...
Central carbon metabolism in cancer -1.71 4.44e-2 67/70 (95.71%) AKT1;FGFR1;HK3;...
Dilated cardiomyopathy -1.71 4.72e-2 86/96 (89.58%) ITGB1;ITGB3;ITGB4;...
Aldosterone synthesis and secretion -1.75 3.49e-2 85/98 (86.73%) ADCY9;NR4A1;CACNA1D;...
Endocrine and other factor-regulated calcium reabsorpti... -1.76 3.30e-2 49/53 (92.45%) AP2A2;CLTCL1;KL;...
TNF signaling pathway -1.77 2.84e-2 103/112 (91.96%) CXCL2;CCL20;PIK3R1;...
Protein digestion and absorption -1.79 2.69e-2 78/103 (75.73%) COL4A4;COL1A1;COL4A6;...
Mineral absorption -1.79 2.66e-2 48/60 (80%) MT1E;SLC39A4;MT1HL1;...
Amoebiasis -1.84 1.81e-2 99/102 (97.06%) COL4A4;COL1A1;RAB5B;...
Glycolysis / Gluconeogenesis -1.85 2.03e-2 56/67 (83.58%) DLD;ENO3;ALDOA;...
Glucagon signaling pathway -1.86 1.48e-2 89/107 (83.18%) FBP2;PLCB4;AKT3;...
Fructose and mannose metabolism -1.87 1.73e-2 30/33 (90.91%) PMM1;GMPPA;AKR1B10;...
Galactose metabolism -1.90 1.78e-2 26/31 (83.87%) B4GALT1;AKR1B10;HK3;...
Insulin resistance -1.91 1.11e-2 96/108 (88.89%) PPARGC1A;PYGL;FOXO1;...
Morphine addiction -1.91 1.48e-2 80/91 (87.91%) GNAI2;GABRB3;DRD1;...
Insulin secretion -1.93 1.48e-2 75/86 (87.21%) KCNN3;CREB3L2;ADCY9;...
Type II diabetes mellitus -2.06 0.00e+0 42/46 (91.3%) PRKCD;HK3;TNF;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H