Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMC0GSJ)

• Drug Name: Efavirenz Drug Info
• Synonyms: EFV; EFZ; Eravirenz; Stocrin; Sustiva; DMP 266; L 743726; DMP-266; L-741211; L-743725; L-743726; Stocrin (TN); Strocin (TM); Sustiva (TM); Sustiva (TN); Efavirenz (JAN/INN); L-743,726; Zoxazin-2-one; Efavirenz, (S)-isomer; Met-SDF-1.beta. & Efavirenz; Met-Stromal Cell-derived Factor-1.beta. (Human) & Efavirenz; (-)-Efavirenz; (4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one; (4S)-6-Chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one; (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one; (4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one; (S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-ben; (S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one; (S)-6-Chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one; 2H-3,1-Benzoxazin-2-one, 6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)-(9; 6-chloro-4-(2-cyclopropyl-1-ethynyl)-4-trifluoromethyl-(4S)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one
• Therapeutic Class: Anti-HIV Agents
• Cross-matching ID:
  PubChem CID: 64139
  ChEBI ID: CHEMBL223228
  CAS Number: CAS 154598-52-4
  TTD Drug ID: D07HVY
  VARIDT Drug ID: DR00412
  INTEDE Drug ID: DR0560
  ACDINA Drug ID: D00222

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.35	0.00e+0	34/36 (94.44%)	FEN1;MCM3;RFC3;...
Base excision repair	2.04	0.00e+0	29/33 (87.88%)	FEN1;NEIL3;PARP2;...
Retinol metabolism	-1.58	4.92e-2	41/68 (60.29%)	DGAT1;CYP2C8;RETSAT;...
Ferroptosis	-1.59	4.77e-2	36/41 (87.8%)	SLC7A11;ACSL5;SLC3A2;...
ECM-receptor interaction	-1.61	4.36e-2	80/88 (90.91%)	LAMC1;COL9A3;COL6A2;...
Epithelial cell signaling in Helicobacter pylori infect...	-1.62	4.21e-2	62/70 (88.57%)	ATP6V1H;ADAM17;HBEGF;...
Collecting duct acid secretion	-1.63	4.15e-2	22/27 (81.48%)	ATP6V1C1;ATP6V1B2;ATP6V1A;...
Fatty acid biosynthesis	-1.63	4.05e-2	16/18 (88.89%)	ACACB;ACSL5;HSD17B8;...
Vitamin digestion and absorption	-1.63	4.23e-2	17/24 (70.83%)	MMACHC;CUBN;ABCC1;...
Bladder cancer	-1.64	4.24e-2	40/41 (97.56%)	CDKN2A;E2F3;FGFR3;...
Pertussis	-1.65	3.97e-2	64/76 (84.21%)	CALML3;C2;CALML4;...
Lysosome	-1.68	3.20e-2	115/128 (89.84%)	CTNS;HEXB;CD63;...
Phagosome	-1.71	2.34e-2	118/152 (77.63%)	HGS;CALR;ATP6V1B2;...
alpha-Linolenic acid metabolism	-1.74	1.67e-2	17/25 (68%)	PLA2G2D;PLA2G1B;PLA2G4C;...
Fat digestion and absorption	-1.74	1.57e-2	35/43 (81.4%)	PLA2G2D;PNLIPRP2;PLA2G1B;...
Synthesis and degradation of ketone bodies	-1.77	1.08e-2	9/10 (90%)	BDH2;HMGCS2;ACAT2;...
Linoleic acid metabolism	-1.79	9.25e-3	21/29 (72.41%)	PLA2G2D;PLA2G1B;PLA2G4C;...
Rheumatoid arthritis	-1.79	8.72e-3	78/93 (83.87%)	CXCL6;ATP6V1B2;HLA-DOB;...
Protein digestion and absorption	-1.79	9.45e-3	78/103 (75.73%)	PRCP;PRSS1;KCNQ1;...
Staphylococcus aureus infection	-1.84	4.42e-3	72/95 (75.79%)	SELP;DSG1;KRT10;...
Complement and coagulation cascades	-1.84	4.05e-3	76/85 (89.41%)	PROCR;SERPINC1;CD55;...
IL-17 signaling pathway	-1.86	4.50e-3	84/94 (89.36%)	IL6;IL1B;MMP9;...
Terpenoid backbone biosynthesis	-1.87	5.06e-3	18/22 (81.82%)	DHDDS;MVD;HMGCS2;...
Metabolism of xenobiotics by cytochrome P450	-1.89	5.78e-3	49/77 (63.64%)	MGST3;GSTM3;CYP3A4;...
Nicotinate and nicotinamide metabolism	-1.92	4.05e-3	25/35 (71.43%)	SIRT2;SIRT3;NMRK1;...
Steroid hormone biosynthesis	-2.01	3.24e-3	43/61 (70.49%)	CYP3A7;HSD17B8;HSD17B2;...
Legionellosis	-2.03	4.05e-3	51/57 (89.47%)	HSPD1;IL6;IL1B;...
PPAR signaling pathway	-2.04	5.40e-3	66/74 (89.19%)	ME1;ACSL5;ACOX1;...
Mineral absorption	-2.09	0.00e+0	48/60 (80%)	HEPH;ATP1A1;MT2A;...
Steroid biosynthesis	-2.11	0.00e+0	19/20 (95%)	LSS;LIPA;NSDHL;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	10uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 10uM	24H	Show ▼