Details of the Drug Pharmacogenomic Perturbation Atlas

Exherin Drug Info

Exherin; 229971-81-7; UNII-B058ME29VU; ADH-1; ADH1; B058ME29VU; ADH 1; ADH-1 pepide; Exherin (ADH-1); ADH-1;ADH1;ADH 1; SCHEMBL13857500; CHEMBL3818130; ZINC3939935; ADH-10001; AKOS030526741; CS-3450; L-Cysteinamide, N-acetyl-L-cysteinyl-L-histidyl-l-alanyl-L-valyl-, cyclic (1-5)-disulfide; HY-13541

Therapeutic Class

Anticancer Agents

Cross-matching ID

PubChem CID

9916058

CAS Number

CAS 229971-81-7

TTD Drug ID

D0KK9E

General Information of Drug (ID: DMC1I56)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Graft-versus-host disease	2.27	0.00e+0	32/42 (76.19%)	HLA-DPA1;HLA-A;HLA-DRA;...
Antigen processing and presentation	2.16	0.00e+0	60/78 (76.92%)	HSPA8;CTSS;HLA-DPA1;...
Type I diabetes mellitus	2.09	0.00e+0	38/43 (88.37%)	HLA-DPA1;HLA-A;HLA-DRA;...
Pentose phosphate pathway	1.90	1.44e-2	25/30 (83.33%)	PFKL;RPIA;FBP1;...
Oxidative phosphorylation	1.89	1.38e-2	93/133 (69.92%)	COX5B;ATP6V1D;NDUFB5;...
Rheumatoid arthritis	1.89	1.34e-2	78/93 (83.87%)	CXCL8;CCL20;TLR4;...
Th17 cell differentiation	1.86	1.48e-2	95/107 (88.79%)	TGFBR2;IL2RB;HLA-DPA1;...
Phagosome	1.83	1.58e-2	118/152 (77.63%)	CTSS;TLR4;CYBB;...
Allograft rejection	1.80	1.54e-2	32/38 (84.21%)	HLA-DPA1;HLA-A;HLA-DRA;...
Measles	1.77	2.42e-2	133/139 (95.68%)	CYCS;TNFAIP3;HSPA8;...
PD-L1 expression and PD-1 checkpoint pathway in cancer	1.73	4.19e-2	79/89 (88.76%)	TLR4;CD3D;EML4;...
Staphylococcus aureus infection	1.72	4.03e-2	72/95 (75.79%)	DEFB1;KRT18;HLA-DPA1;...
Non-alcoholic fatty liver disease	1.72	3.81e-2	126/155 (81.29%)	CYCS;CXCL8;COX5B;...
Influenza A	1.70	4.11e-2	156/172 (90.7%)	CYCS;CXCL8;OAS2;...
Mineral absorption	1.69	4.38e-2	48/60 (80%)	MT1E;MT1F;MT1HL1;...
Viral myocarditis	1.69	4.10e-2	53/60 (88.33%)	CYCS;HLA-DPA1;HLA-A;...
Cellular senescence	1.69	3.93e-2	139/156 (89.1%)	CXCL8;HIPK3;TGFBR2;...
TNF signaling pathway	1.68	3.90e-2	103/112 (91.96%)	TNFAIP3;CCL20;CXCL5;...
Prion disease	1.66	4.12e-2	209/273 (76.56%)	CYCS;HSPA8;COX5B;...
Vibrio cholerae infection	1.65	4.09e-2	44/50 (88%)	GNAS;ATP6V1D;TJP2;...
Tuberculosis	1.64	4.61e-2	159/180 (88.33%)	CYCS;CTSS;TLR4;...
Systemic lupus erythematosus	1.64	4.55e-2	45/135 (33.33%)	SNRPB;HLA-DPA1;HLA-DRA;...
Ubiquitin mediated proteolysis	-1.75	4.29e-2	87/140 (62.14%)	CBLC;NEDD4L;CDC34;...
alpha-Linolenic acid metabolism	-1.78	4.63e-2	17/25 (68%)	PLA2G4C;PLA2G10;PLA2G12A;...
Ether lipid metabolism	-1.88	1.64e-2	32/49 (65.31%)	PLD3;PLA2G4C;PLA2G10;...
ECM-receptor interaction	-1.93	1.64e-2	80/88 (90.91%)	FRAS1;CD44;TNXB;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H

MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.04uM - 10uM	24H

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 10uM	24H