General Information of Drug (ID: DMC29LV)

Drug Name
ONO-4059 Drug Info
Cross-matching ID
PubChem CID
54755438
TTD Drug ID
D02MRX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
N-Glycan biosynthesis 2.04 5.42e-3 38/50 (76%) MAN1A2;DPM3;DPAGT1;...
Ribosome 1.92 1.08e-2 113/158 (71.52%) MRPL34;MRPL19;MRPS2;...
Complement and coagulation cascades 1.78 2.71e-2 76/85 (89.41%) C1R;CFD;SERPING1;...
Base excision repair 1.70 4.74e-2 29/33 (87.88%) PCNA;FEN1;POLE2;...
Malaria -1.75 1.37e-2 44/50 (88%) CD81;THBS3;IL1B;...
AGE-RAGE signaling pathway in diabetic complications -1.75 1.42e-2 97/100 (97%) PLCB4;FN1;PLCD1;...
Toxoplasmosis -1.75 1.28e-2 103/112 (91.96%) HLA-DQB1;MAP2K3;LAMC1;...
Fc gamma R-mediated phagocytosis -1.75 1.33e-2 79/97 (81.44%) PIK3R1;PRKCD;SPHK1;...
Osteoclast differentiation -1.77 1.28e-2 117/127 (92.13%) MAP2K1;FYN;CSF1;...
Yersinia infection -1.77 1.33e-2 120/137 (87.59%) MAP2K3;PIK3CB;ARHGEF28;...
Epstein-Barr virus infection -1.78 1.38e-2 189/202 (93.56%) TYK2;CD19;PSMD4;...
T cell receptor signaling pathway -1.78 1.33e-2 93/104 (89.42%) HRAS;ZAP70;SOS2;...
Focal adhesion -1.79 1.33e-2 180/201 (89.55%) SOS2;PDPK1;RASGRF1;...
Apoptosis -1.79 1.33e-2 126/168 (75%) CTSL;LMNB2;CTSO;...
Viral carcinogenesis -1.82 1.13e-2 149/203 (73.4%) CHEK1;IRF7;CDC20;...
Salmonella infection -1.83 1.05e-2 198/249 (79.52%) TRADD;RRAS;GCC2;...
Tuberculosis -1.85 9.60e-3 159/180 (88.33%) ITGAM;CALML5;IL1B;...
Bacterial invasion of epithelial cells -1.85 1.02e-2 59/77 (76.62%) CLTA;ACTB;ARPC1A;...
B cell receptor signaling pathway -1.88 5.82e-3 71/81 (87.65%) HRAS;SOS2;CD22;...
TNF signaling pathway -1.90 4.43e-3 103/112 (91.96%) MAP2K1;PTGS2;MAP3K8;...
Graft-versus-host disease -1.91 4.75e-3 32/42 (76.19%) PRF1;CD86;CD80;...
VEGF signaling pathway -1.92 4.09e-3 50/59 (84.75%) MAP2K1;PTGS2;PIK3R1;...
Rheumatoid arthritis -1.92 4.43e-3 78/93 (83.87%) TNFRSF11A;ATP6V1H;ITGAL;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.93 4.83e-3 79/89 (88.76%) PIK3R1;IFNGR1;MAP2K3;...
C-type lectin receptor signaling pathway -1.94 3.99e-3 93/104 (89.42%) CALML5;IL1B;PIK3R1;...
Inflammatory bowel disease -1.94 4.43e-3 58/65 (89.23%) IL1B;HLA-DQA1;IFNGR1;...
Th17 cell differentiation -1.95 4.98e-3 95/107 (88.79%) TYK2;IL1B;HLA-DQA1;...
Shigellosis -1.95 5.70e-3 180/246 (73.17%) PLCD1;IL1B;GABARAPL1;...
Adherens junction -1.97 6.65e-3 63/71 (88.73%) PARD3;MET;TCF7;...
Th1 and Th2 cell differentiation -1.98 5.32e-3 80/92 (86.96%) TYK2;HLA-DQA1;IFNGR1;...
Leishmaniasis -2.04 3.32e-3 67/77 (87.01%) PTGS2;ITGAM;IL1B;...
Epithelial cell signaling in Helicobacter pylori infect... -2.06 4.43e-3 62/70 (88.57%) PLCG2;CXCR2;ATP6V0D1;...
NF-kappa B signaling pathway -2.06 6.65e-3 90/104 (86.54%) IL1B;BLNK;TRADD;...
Type I diabetes mellitus -2.10 1.33e-2 38/43 (88.37%) PRF1;CD86;CD80;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Mantle cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MINO CVCL_4965 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H