Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMC4RNA)

Drug Name
TAK-733 Drug Info
Synonyms
TAK-733; 1035555-63-5; TAK733; TAK 733; UNII-5J61HSP0QJ; (R)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione; 5J61HSP0QJ; CHEMBL1615025; 3-[(2r)-2,3-Dihydroxypropyl]-6-Fluoro-5-[(2-Fluoro-4-Iodophenyl)amino]-8-Methylpyrido[2,3-D]pyrimidine-4,7(3h,8h)-Dione; MLS006011054; SCHEMBL1528606; GTPL9911; DTXSID20648089; MolPort-023-293-497; RCLQNICOARASSR-SECBINFHSA-N; example 18 [US8470837]; AOB87182; EX-A2164; BCP06625
Cross-matching ID
PubChem CID
24963252
ChEBI ID
CHEMBL1615025
CAS Number
CAS 1035555-63-5
TTD Drug ID
D0I3RD

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.17 0.00e+0 93/133 (69.92%) ATP6V0E1;LHPP;NDUFB1;...
Metabolism of xenobiotics by cytochrome P450 2.15 0.00e+0 49/77 (63.64%) GSTM3;GSTP1;GSTK1;...
Lysosome 2.07 0.00e+0 115/128 (89.84%) LITAF;CTSA;TPP1;...
Other glycan degradation 2.00 0.00e+0 13/18 (72.22%) FUCA1;HEXA;MAN2B2;...
Steroid biosynthesis 1.97 0.00e+0 19/20 (95%) TM7SF2;SC5D;LSS;...
Valine, leucine and isoleucine degradation 1.93 0.00e+0 42/48 (87.5%) HMGCS1;ALDH2;HMGCL;...
Tryptophan metabolism 1.93 0.00e+0 35/42 (83.33%) ALDH2;CAT;CYP1A1;...
Butanoate metabolism 1.87 8.61e-3 23/28 (82.14%) HMGCS1;BDH2;HMGCL;...
Peroxisome 1.84 1.22e-2 72/82 (87.8%) PHYH;GSTK1;ECH1;...
ABC transporters 1.84 1.10e-2 37/45 (82.22%) ABCC1;DEFB1;ABCB6;...
Glycosaminoglycan degradation 1.84 1.00e-2 19/19 (100%) HGSNAT;IDS;HEXA;...
Endocrine and other factor-regulated calcium reabsorpti... 1.77 2.07e-2 49/53 (92.45%) GNAS;ATP2B4;ADCY9;...
Mitophagy 1.76 2.22e-2 56/68 (82.35%) OPTN;RRAS;FIS1;...
beta-Alanine metabolism 1.76 2.07e-2 25/30 (83.33%) ALDH3A1;ALDH2;ALDH3B1;...
Cardiac muscle contraction 1.76 1.93e-2 64/87 (73.56%) TPM1;TPM2;TNNC1;...
Fatty acid degradation 1.76 1.81e-2 40/43 (93.02%) ALDH2;CPT1A;ACADVL;...
Sulfur metabolism 1.71 2.67e-2 9/10 (90%) SELENBP1;TST;ETHE1;...
Necroptosis 1.69 3.06e-2 113/159 (71.07%) TNFSF10;CAPN1;PYCARD;...
Steroid hormone biosynthesis 1.69 2.97e-2 43/61 (70.49%) AKR1C3;AKR1C2;AKR1C1;...
Vibrio cholerae infection 1.67 3.58e-2 44/50 (88%) GNAS;ADCY9;ATP6V0E1;...
Diabetic cardiomyopathy 1.65 4.13e-2 162/203 (79.8%) NDUFB1;PLCB4;ATP5MC2;...
Cell adhesion molecules 1.63 4.76e-2 118/148 (79.73%) ALCAM;ITGAV;CLDN1;...
Histidine metabolism 1.63 4.61e-2 16/22 (72.73%) ALDH3A1;ALDH2;ALDH3B1;...
IL-17 signaling pathway -1.58 4.39e-2 84/94 (89.36%) CEBPB;CHUK;TRAF2;...
Spinocerebellar ataxia -1.60 3.90e-2 128/143 (89.51%) MYOD1;GRIN1;PSMD9;...
Legionellosis -1.66 2.17e-2 51/57 (89.47%) CYCS;IL6;HSPA6;...
mRNA surveillance pathway -1.67 2.15e-2 71/98 (72.45%) PPP2R3B;PAPOLA;RNMT;...
RNA polymerase -1.68 2.13e-2 23/31 (74.19%) POLR3D;POLR3F;POLR2K;...
Base excision repair -1.70 1.88e-2 29/33 (87.88%) HMGB1;POLD3;POLE;...
Non-homologous end-joining -1.71 1.84e-2 11/13 (84.62%) POLM;MRE11;DCLRE1C;...
RNA degradation -1.71 1.96e-2 53/79 (67.09%) LSM7;LSM3;LSM2;...
Oocyte meiosis -1.74 1.23e-2 90/129 (69.77%) ADCY1;PPP2R1B;YWHAH;...
Homologous recombination -1.76 8.36e-3 35/41 (85.37%) MRE11;RPA1;BRCA2;...
Proteasome -1.81 4.26e-3 44/46 (95.65%) PSMA1;PSME4;PSME3;...
One carbon pool by folate -1.85 4.07e-3 15/20 (75%) MTHFD1;GART;SHMT2;...
Nucleotide excision repair -1.88 1.92e-3 40/47 (85.11%) CDK7;ERCC8;RAD23A;...
Pyrimidine metabolism -1.95 1.42e-3 40/56 (71.43%) ENPP1;DPYD;DHODH;...
Progesterone-mediated oocyte maturation -1.98 1.60e-3 75/100 (75%) ANAPC1;MAD1L1;PKMYT1;...
Mismatch repair -2.07 0.00e+0 22/23 (95.65%) RPA1;RFC1;POLD3;...
Fanconi anemia pathway -2.19 0.00e+0 36/54 (66.67%) RPA1;BRCA2;BRIP1;...
Ribosome biogenesis in eukaryotes -2.27 0.00e+0 52/108 (48.15%) POP5;CSNK2A2;MPHOSPH10;...
RNA transport -2.31 0.00e+0 128/186 (68.82%) TGS1;EIF4A1;MAGOH;...
Spliceosome -2.35 0.00e+0 101/150 (67.33%) DDX23;SNRNP200;RBM8A;...
DNA replication -2.48 0.00e+0 34/36 (94.44%) RNASEH1;RPA1;RFC1;...
Cell cycle -2.52 0.00e+0 110/124 (88.71%) MAD1L1;PKMYT1;ORC1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H