General Information of Drug (ID: DMC50ME)

Drug Name
Debrisoquin Drug Info
Synonyms
Debrisochinum; Debrisoquina; Debrisoquine; Debrisoquinum; Declinax; Equitonil; Isocaramidine; Tendor; DEBRISOQUIN SULFATE; Debrisoquin hemisulfate; Debrisoquine sulfate; Isocaramidine sulfate; Debrisoquina [INN-Spanish]; Debrisoquine [INN:BAN]; Debrisoquinum [INN-Latin]; Ro 5-3307/1; Sulfuric acid compound with 3,4-dihydro-2(1H)-isoquinolinecarboximidamide (1:1); 1,2,3, 4-Tetrahydro-isoquinoline-2-carboxamidine sulfate; 2(1H)-Isoquinolinecarboxamidine, 3,4-dihydro-(7CI,8CI); 2(1H)-Isoquinolinecarboxamidine, 3,4-dihydro-, sulfate (2:1); 2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-, sulfate (2:1); 2-Amidino-1,2,3,4-tetrahydroisoquinoline; 3,4-Dihydro-2(1H)-isoquinolinecarboxamidine; 3,4-Dihydro-2(1H)-isoquinolinecarboxamidine sulfate (2:1); 3,4-Dihydro-2(1H)-isoquinolinecarboximidamide; 3,4-Dihydro-2(1H;)-isoquinoline carboxamidine sulfate; 3,4-dihydro-1H-isoquinoline-2-carboximidamide; 3,4-dihydroisoquinoline-2(1H)-carboximidamide
Therapeutic ClassAntihypertensive Agents
Cross-matching ID
PubChem CID
2966
ChEBI ID
CHEMBL169901
CAS Number
CAS 1131-64-2
TTD Drug ID
D0MP5H
VARIDT Drug ID
DR01479
INTEDE Drug ID
DR0427

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Staphylococcus aureus infection 1.83 1.04e-1 72/95 (75.79%) CFI;HLA-DOB;HLA-DQB1;...
Complement and coagulation cascades 1.73 1.30e-1 76/85 (89.41%) PLAT;SERPINA1;CFI;...
Systemic lupus erythematosus 1.72 1.14e-1 45/135 (33.33%) HLA-DOB;HLA-DQB1;C2;...
Asthma 1.70 1.06e-1 25/31 (80.65%) FCER1A;HLA-DOB;FCER1G;...
Intestinal immune network for IgA production 1.62 1.79e-1 38/48 (79.17%) HLA-DOB;HLA-DQB1;CD86;...
RNA polymerase 1.58 1.95e-1 23/31 (74.19%) POLR2L;POLR3B;POLR3G;...
Fluid shear stress and atherosclerosis 1.48 3.91e-1 123/139 (88.49%) PLAT;RAC2;CYBA;...
Histidine metabolism 1.46 3.80e-1 16/22 (72.73%) ALDH7A1;MAOA;ALDH2;...
Arachidonic acid metabolism 1.40 5.49e-1 48/61 (78.69%) ALOX5;PLA2G2A;GPX3;...
Fc epsilon RI signaling pathway 1.39 5.42e-1 57/68 (83.82%) ALOX5;RAC2;FCER1A;...
Type II diabetes mellitus 1.38 5.28e-1 42/46 (91.3%) SOCS1;PKM;MAPK10;...
Linoleic acid metabolism 1.37 5.42e-1 21/29 (72.41%) PLA2G2A;PLAAT3;PLA2G10;...
Allograft rejection 1.36 5.31e-1 32/38 (84.21%) HLA-DOB;HLA-DQB1;FAS;...
Tryptophan metabolism 1.35 5.33e-1 35/42 (83.33%) ALDH7A1;MAOA;KMO;...
Apoptosis 1.34 5.16e-1 126/168 (75%) CTSK;CTSH;CASP10;...
alpha-Linolenic acid metabolism 1.32 5.76e-1 17/25 (68%) PLA2G2A;FADS2;PLAAT3
Ascorbate and aldarate metabolism 1.32 5.51e-1 15/30 (50%) ALDH7A1;UGT2B28;ALDH2;...
Viral myocarditis 1.32 5.23e-1 53/60 (88.33%) RAC2;CAV1;HLA-DOB;...
Ribosome 1.31 4.99e-1 113/158 (71.52%) RPL36;RPS5;RPL13;...
Sulfur metabolism 1.29 5.60e-1 9/10 (90%) PAPSS1;TST;PAPSS2;...
Retinol metabolism 1.29 5.38e-1 41/68 (60.29%) ADH1B;UGT2B28;ALDH1A2;...
Coronavirus disease 1.27 5.65e-1 215/232 (92.67%) F13A1;OAS3;OAS1;...
Glycosaminoglycan biosynthesis 1.26 5.80e-1 40/58 (68.97%) HS3ST1;EXT1;EXTL2;...
Neomycin, kanamycin and gentamicin biosynthesis 1.26 5.82e-1 5/5 (100%) HK2;HK3;HKDC1
Arginine and proline metabolism 1.26 5.64e-1 39/50 (78%) ALDH7A1;MAOA;ALDH2;...
Lysine degradation 1.25 5.48e-1 51/63 (80.95%) ALDH7A1;SUV39H1;ALDH2;...
Cytosolic DNA-sensing pathway 1.25 5.36e-1 52/63 (82.54%) AIM2;POLR2L;POLR3B;...
Influenza A 1.25 5.24e-1 156/172 (90.7%) TNFSF10;HLA-DOB;OAS3;...
Fatty acid biosynthesis 1.24 5.52e-1 16/18 (88.89%) FASN;ACSL4;ACSL1;...
Pentose and glucuronate interconversions 1.23 5.47e-1 17/34 (50%) DCXR;UGT2B28;AKR1B1;...
Oxidative phosphorylation -1.30 4.15e-1 93/133 (69.92%) COX7A2L;NDUFAB1;NDUFS2;...
Huntington disease -1.31 4.11e-1 233/306 (76.14%) NRBF2;GRIA3;IFT57;...
Alzheimer disease -1.31 4.23e-1 279/369 (75.61%) ULK1;EIF2S1;NDUFV1;...
Human immunodeficiency virus 1 infection -1.32 4.20e-1 189/212 (89.15%) BAX;CD3G;PRKCA;...
Human cytomegalovirus infection -1.34 4.16e-1 201/225 (89.33%) GSK3B;PTGER4;RHEB;...
Glyoxylate and dicarboxylate metabolism -1.35 3.84e-1 23/30 (76.67%) HAO1;PCCB;ACO2;...
Synthesis and degradation of ketone bodies -1.36 3.60e-1 9/10 (90%) BDH1;HMGCS2;ACAT2;...
Lipid and atherosclerosis -1.37 3.66e-1 190/215 (88.37%) GSK3B;IL18;NOX1;...
Spinocerebellar ataxia -1.37 3.80e-1 128/143 (89.51%) TBP;PSMA3;PSMD12;...
Oxytocin signaling pathway -1.37 3.94e-1 128/154 (83.12%) PRKAB2;GNAI1;PLCB3;...
Various types of N-glycan biosynthesis -1.37 4.03e-1 26/39 (66.67%) MGAT1;STT3A;B4GALT3;...
Thyroid cancer -1.37 4.18e-1 36/37 (97.3%) CCDC6;TFG;BAX;...
Pathways of neurodegeneration -1.40 4.22e-1 354/475 (74.53%) COX7A2L;MAPK13;FRAT2;...
Glutamatergic synapse -1.40 4.10e-1 97/114 (85.09%) GRM3;GNAI1;PLCB3;...
Inositol phosphate metabolism -1.41 4.16e-1 66/73 (90.41%) INPP5E;PIK3CA;MTMR6;...
GABAergic synapse -1.46 3.33e-1 76/89 (85.39%) PRKCA;GABRA5;GABRR1;...
Nitrogen metabolism -1.46 3.34e-1 16/17 (94.12%) CA12;GLUD2;GLUD1
Kaposi sarcoma-associated herpesvirus infection -1.48 3.20e-1 172/193 (89.12%) HLA-G;FOS;HIF1A;...
NF-kappa B signaling pathway -1.48 3.41e-1 90/104 (86.54%) CD14;BCL2L1;CXCL3;...
Thyroid hormone signaling pathway -1.50 3.36e-1 112/121 (92.56%) PLCE1;AKT3;PLCB3;...
Arginine biosynthesis -1.52 2.93e-1 17/22 (77.27%) ASS1;GOT2;GLUD2;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.53 3.02e-1 79/89 (88.76%) CD3G;FOS;MAP2K3;...
Pertussis -1.53 3.33e-1 64/76 (84.21%) IL1A;IL6;IRAK4;...
Th17 cell differentiation -1.55 3.21e-1 95/107 (88.79%) CD3G;RUNX1;FOS;...
Caffeine metabolism -1.59 2.73e-1 5/6 (83.33%) NAT2;CYP2A6;NAT1
Alanine, aspartate and glutamate metabolism -1.60 3.01e-1 27/37 (72.97%) ASRGL1;NIT2;ASS1;...
mTOR signaling pathway -1.62 3.21e-1 114/154 (74.03%) RPS6KA1;TELO2;MIOS;...
Proteasome -1.64 3.94e-1 44/46 (95.65%) PSMF1;PSMA3;PSMD12;...
Glycosphingolipid biosynthesis -1.76 2.01e-1 37/57 (64.91%) FUT9;B3GALNT1;B4GALNT1;...
Primary immunodeficiency -1.77 3.25e-1 33/38 (86.84%) ADA;TAP2;CD8A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 20uM 72H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 24H