Details of the Drug Pharmacogenomic Perturbation Atlas

RAF265 Drug Info

RAF265; 927880-90-8; CHIR-265; RAF 265; RAF-265; CHIR 265; RAF265 (CHIR-265); 1-Methyl-5-[[2-[5-(trifluoromethyl)-1h-imidazol-2-yl]-4-pyridinyl]oxy]-n-[4-(trifluoromethyl)phenyl]-1h-benzimidazol-2-amine; CHIR265; RAF265(CHIR-265); UNII-8O434L3768; 8O434L3768; 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine; 1-Methyl-5-({2-[5-(Trifluoromethyl)-1h-Imidazol-2-Yl]pyridin-4-Yl}oxy)-N-[4-(Trifluoromethyl)phenyl]-1h-Benzimidazol-2-Amine; PubChem22594

Cross-matching ID

PubChem CID

11656518

ChEBI ID

CHEMBL558752

CAS Number

CAS 927880-90-8

TTD Drug ID

D03AND

General Information of Drug (ID: DMC56T4)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Glycine, serine and threonine metabolism	2.36	0.00e+0	31/40 (77.5%)	PSAT1;PHGDH;CBS;...
Cysteine and methionine metabolism	2.22	4.45e-3	43/50 (86%)	PSAT1;PHGDH;CBS;...
Alanine, aspartate and glutamate metabolism	2.18	2.96e-3	27/37 (72.97%)	ASNS;ASS1;GOT1;...
Arginine biosynthesis	2.01	1.11e-2	17/22 (77.27%)	ASS1;GOT1;GLS2;...
One carbon pool by folate	1.96	1.78e-2	15/20 (75%)	MTHFD2;SHMT2;MTHFD1;...
Ferroptosis	1.86	3.11e-2	36/41 (87.8%)	SLC7A11;SLC3A2;HMOX1;...
Selenocompound metabolism	1.84	2.79e-2	11/17 (64.71%)	CTH;TXNRD1;KYAT3;...
Spliceosome	-1.70	4.51e-2	101/150 (67.33%)	CDC40;PRPF40A;SRSF3;...
Biosynthesis of unsaturated fatty acids	-1.73	3.26e-2	21/27 (77.78%)	ACOX1;ELOVL1;BAAT;...
Focal adhesion	-1.78	1.97e-2	180/201 (89.55%)	PAK6;MAP2K1;PIK3CB;...
Dilated cardiomyopathy	-1.82	1.61e-2	86/96 (89.58%)	DAG1;AGT;ITGA2B;...
Hippo signaling pathway	-1.83	1.69e-2	120/186 (64.52%)	PAK1;CSNK1D;CTNNA1;...
Terpenoid backbone biosynthesis	-1.83	1.80e-2	18/22 (81.82%)	ICMT;MVD;PCYOX1;...
Bacterial invasion of epithelial cells	-1.84	1.69e-2	59/77 (76.62%)	ARPC1B;ARPC1A;RHOA;...
ECM-receptor interaction	-1.84	2.25e-2	80/88 (90.91%)	ITGA2B;ITGB5;SDC4;...
Cholesterol metabolism	-1.93	1.13e-2	44/50 (88%)	SOAT1;CYP27A1;APOB;...
Steroid biosynthesis	-2.50	0.00e+0	19/20 (95%)	LBR;DHCR24;TM7SF2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow

Neuroblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
SH-SY5Y	CVCL_0019	Homo sapiens	0.04uM - 10uM	24H

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H

MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H

Normal (Epithelial)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HME1	CVCL_2950	Homo sapiens	0.04uM - 10uM	24H

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	0.04uM - 10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	0.04uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H

A549/Asc-1	CVCL_YA87	Homo sapiens	0.04uM - 10uM	24H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	0.04uM - 10uM	24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H

SK-L	CVCL_1699	Homo sapiens	0.04uM - 10uM	24H

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.04uM - 10uM	24H