Details of the Drug Pharmacogenomic Perturbation Atlas

Berberine Drug Info

berberine; 2086-83-1; Berberin; Umbellatine; UNII-0I8Y3P32UF; 0I8Y3P32UF; CHEBI:16118; EINECS 218-229-1; Berberal; BRN 3570374; ST055798; 9,10-Dimethoxy-2,3-(methylenedioxy)-7,8,13,13a-tetrahydroberbinium; Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-; 9,10-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium; Berbamine sulphate acid; CHEMBL12089; 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)berbinium; BERBINIUM, 7,8,13,13a-TETRAHYDRO-9,10-DIMETHOXY-2,3-(METHYLE

Cross-matching ID

PubChem CID

2353

ChEBI ID

CHEMBL16118

CAS Number

CAS 2086-83-1

TTD Drug ID

D0W8WB

VARIDT Drug ID

DR00307

General Information of Drug (ID: DMC5Q8X)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Ribosome	2.15	0.00e+0	113/158 (71.52%)	MRPS16;RPL14;RPL36AL;...
Primary bile acid biosynthesis	2.08	0.00e+0	15/17 (88.24%)	HSD17B4;AMACR;SCP2;...
RNA transport	1.94	1.49e-2	128/186 (68.82%)	RAN;XPO1;EIF4B;...
Protein export	1.90	1.12e-2	17/23 (73.91%)	SEC61B;SEC61G;SPCS3;...
Propanoate metabolism	1.79	3.57e-2	30/34 (88.24%)	LDHB;ACAT2;SUCLG2;...
Long-term potentiation	1.77	3.72e-2	61/67 (91.04%)	PRKCA;ATF4;PLCB1;...
Glycolysis / Gluconeogenesis	1.77	3.32e-2	56/67 (83.58%)	PGAM1;LDHB;PFKP;...
Lysine degradation	1.71	4.80e-2	51/63 (80.95%)	PLOD2;ACAT2;DLST;...
Tuberculosis	-1.70	4.99e-2	159/180 (88.33%)	TLR2;TGFB3;AKT1;...
Phagosome	-1.74	3.86e-2	118/152 (77.63%)	STX7;MRC2;ITGB1;...
Toll-like receptor signaling pathway	-1.75	4.03e-2	94/104 (90.38%)	TNF;IFNAR1;NFKBIA;...
Inflammatory bowel disease	-1.77	3.51e-2	58/65 (89.23%)	NFATC1;TLR2;TGFB3;...
Cytokine-cytokine receptor interaction	-1.79	2.59e-2	246/295 (83.39%)	CSF1R;CD40LG;GDF9;...
Legionellosis	-1.81	2.33e-2	51/57 (89.47%)	HSF1;CR1;HSPA1L;...
Asthma	-1.85	1.09e-2	25/31 (80.65%)	IL5;MS4A2;IL3;...
Viral protein interaction with cytokine and cytokine re...	-1.92	6.54e-3	84/100 (84%)	CSF1R;ACKR3;CCL13;...
Malaria	-1.98	0.00e+0	44/50 (88%)	CCL2;MET;IL6;...
Hematopoietic cell lineage	-2.00	0.00e+0	90/99 (90.91%)	ITGA2B;HLA-DRB1;CD33;...
Staphylococcus aureus infection	-2.03	0.00e+0	72/95 (75.79%)	ITGB2;HLA-DRB1;FPR1;...
Rheumatoid arthritis	-2.13	0.00e+0	78/93 (83.87%)	TLR2;TGFB3;ITGB2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H