Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCBV20)

Drug Name
LY-2334737 Drug Info
Synonyms Gem prodrug (cancer), Eli Lilly; Gemcitabine prodrug (cancer), Lilly
Cross-matching ID
PubChem CID
11646777
CAS Number
CAS 892128-60-8
TTD Drug ID
D0F2JY

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Pyruvate metabolism 2.21 0.00e+0 41/47 (87.23%) DLD;ME1;MDH1;...
Citrate cycle (TCA cycle) 2.15 0.00e+0 30/30 (100%) DLD;MDH1;IDH2;...
Glyoxylate and dicarboxylate metabolism 2.01 0.00e+0 23/30 (76.67%) DLD;MDH1;GRHPR;...
Glycine, serine and threonine metabolism 1.96 3.41e-3 31/40 (77.5%) DLD;PGAM1;GNMT;...
Graft-versus-host disease 1.88 1.37e-2 32/42 (76.19%) HLA-DQA1;HLA-C;IL1B;...
Glycolysis / Gluconeogenesis 1.87 1.14e-2 56/67 (83.58%) DLD;PGAM1;TPI1;...
Proteasome 1.85 1.37e-2 44/46 (95.65%) PSMA3;PSMB8;PSMC3;...
Terpenoid backbone biosynthesis 1.81 2.05e-2 18/22 (81.82%) IDI1;DHDDS;PCYOX1;...
DNA replication 1.79 1.82e-2 34/36 (94.44%) RFC5;POLE;FEN1;...
IL-17 signaling pathway 1.77 2.05e-2 84/94 (89.36%) S100A8;S100A7;S100A9;...
Tryptophan metabolism 1.74 3.23e-2 35/42 (83.33%) DLD;KYNU;DHTKD1;...
Lysine degradation 1.74 3.07e-2 51/63 (80.95%) DLD;SUV39H1;DHTKD1;...
Prion disease 1.73 3.15e-2 209/273 (76.56%) CYCS;CYC1;IL1B;...
TNF signaling pathway 1.71 3.61e-2 103/112 (91.96%) CCL20;VCAM1;DNM1L;...
Parkinson disease 1.71 3.37e-2 176/249 (70.68%) CYCS;CYC1;GNAS;...
Cysteine and methionine metabolism 1.67 4.95e-2 43/50 (86%) ADI1;GOT1;MDH1;...
ECM-receptor interaction -1.92 1.90e-2 80/88 (90.91%) TNXB;LAMC1;ITGB1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H