Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCF6SX)

• Drug Name: TAK-491 Drug Info
• Synonyms: TAK 491
• Cross-matching ID:
  PubChem CID: 135409642
  ChEBI ID: CHEMBL2028661
  CAS Number: CAS 863031-21-4
  TTD Drug ID: D0A2RA
  ACDINA Drug ID: D00055

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
TNF signaling pathway	2.07	0.00e+0	103/112 (91.96%)	CXCL5;CXCL3;CCL20;...
Epithelial cell signaling in Helicobacter pylori infect...	1.98	1.24e-2	62/70 (88.57%)	CXCL3;CXCL2;CXCL1;...
IL-17 signaling pathway	1.94	1.24e-2	84/94 (89.36%)	S100A8;S100A9;CXCL5;...
Fluid shear stress and atherosclerosis	1.85	2.48e-2	123/139 (88.49%)	CALML5;MEF2C;MMP2;...
Amoebiasis	1.85	2.23e-2	99/102 (97.06%)	CXCL3;CD14;CXCL2;...
Rheumatoid arthritis	1.84	2.68e-2	78/93 (83.87%)	CXCL5;CXCL3;ANGPT1;...
Legionellosis	1.79	3.89e-2	51/57 (89.47%)	EEF1A2;CXCL3;CD14;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲