Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCGF3U)

Drug Name
NNC052090 Drug Info
Synonyms NNC 05-2090
Cross-matching ID
PubChem CID
9888030
ChEBI ID
CHEMBL1446457
TTD Drug ID
D0P3KI
VARIDT Drug ID
DR01089

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.50 0.00e+0 19/20 (95%) MSMO1;SQLE;DHCR24;...
PPAR signaling pathway 2.11 0.00e+0 66/74 (89.19%) SCD;HMGCS1;FABP4;...
Retinol metabolism 1.93 1.03e-2 41/68 (60.29%) ALDH1A2;DHRS3;ALDH1A3;...
Biosynthesis of unsaturated fatty acids 1.81 3.59e-2 21/27 (77.78%) SCD;FADS1;ELOVL6;...
Terpenoid backbone biosynthesis 1.80 2.87e-2 18/22 (81.82%) HMGCS1;IDI1;ACAT2;...
Oxidative phosphorylation 1.73 4.78e-2 93/133 (69.92%) COX7C;COX6C;COX7B;...
Propanoate metabolism 1.72 4.69e-2 30/34 (88.24%) ACAT2;ACACA;PCCA;...
Pyruvate metabolism 1.70 5.00e-2 41/47 (87.23%) ACAT2;ACACA;ME2;...
Th1 and Th2 cell differentiation -1.66 4.99e-2 80/92 (86.96%) CHUK;IL4R;RELA;...
Intestinal immune network for IgA production -1.69 4.76e-2 38/48 (79.17%) TGFB1;HLA-DPB1;HLA-DPA1;...
Graft-versus-host disease -1.74 2.91e-2 32/42 (76.19%) HLA-DPB1;HLA-DPA1;HLA-DRB1;...
Proteasome -1.74 3.23e-2 44/46 (95.65%) PSMA2;PSMB2;PSMD7;...
Viral myocarditis -1.85 7.27e-3 53/60 (88.33%) CCND1;CXADR;EIF4G2;...
Autoimmune thyroid disease -1.87 6.93e-3 46/53 (86.79%) HLA-DPB1;HLA-DPA1;HLA-DRB1;...
Cell adhesion molecules -1.92 4.85e-3 118/148 (79.73%) CD58;SDC2;CLDN1;...
Systemic lupus erythematosus -1.95 1.94e-3 45/135 (33.33%) FCGR3B;SNRPB;FCGR2A;...
Spliceosome -1.97 0.00e+0 101/150 (67.33%) LSM4;CDC5L;AQR;...
Ribosome biogenesis in eukaryotes -1.99 0.00e+0 52/108 (48.15%) GNL3L;POP7;RAN;...
Allograft rejection -2.06 0.00e+0 32/38 (84.21%) HLA-DPB1;HLA-DPA1;HLA-DRB1;...
Asthma -2.44 0.00e+0 25/31 (80.65%) HLA-DPB1;HLA-DPA1;HLA-DRB1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 10uM 24H
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H