Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCGWBJ)

Drug Name
Epigallocatechin gallate Drug Info
Synonyms
(-)-Epigallocatechin gallate; EGCG; 989-51-5; Epigallocatechin 3-gallate; Epigallocatechin-3-gallate; Tea catechin; (-)-Epigallocatechin-3-o-gallate; Teavigo; Epigallocatechin-3-monogallate; (-)-Epigallocatechol gallate; (2R,3R)-5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4,5-trihydroxybenzoate; Catechin deriv; UNII-BQM438CTEL; Green tea extract; CCRIS 3729; (-)-epigallocatechin 3-gallate; C22H18O11; BQM438CTEL; (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl; EGCG analogs; EGCG, Anagen; Epigallocatechin gallate analogs, Anagen; Epigallocatechin gallate, Anagen; GTPs,Anagen; Green tea polyphenols, Anagen; EPIGALOCATECHIN GALLATE
Cross-matching ID
PubChem CID
65064
ChEBI ID
CHEMBL297453
CAS Number
CAS 989-51-5
TTD Drug ID
D0U2BH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.72 0.00e+0 34/36 (94.44%) RNASEH2A;RPA2;MCM7;...
Spliceosome 2.59 0.00e+0 101/150 (67.33%) HSPA8;SRSF7;FUS;...
Cell cycle 2.51 0.00e+0 110/124 (88.71%) PLK1;CDC20;MAD2L1;...
Nucleotide excision repair 2.27 0.00e+0 40/47 (85.11%) RPA2;RFC3;POLE2;...
Mismatch repair 2.20 0.00e+0 22/23 (95.65%) RPA2;RFC3;LIG1;...
Homologous recombination 2.20 0.00e+0 35/41 (85.37%) RPA2;RAD54B;RPA3;...
Base excision repair 2.19 0.00e+0 29/33 (87.88%) PARP2;FEN1;POLE2;...
Fanconi anemia pathway 2.18 0.00e+0 36/54 (66.67%) RPA2;FANCI;RPA3;...
Progesterone-mediated oocyte maturation 2.11 0.00e+0 75/100 (75%) PLK1;MAD2L1;CCNA2;...
Pyrimidine metabolism 1.99 0.00e+0 40/56 (71.43%) RRM2;TYMS;RRM1;...
Oocyte meiosis 1.98 0.00e+0 90/129 (69.77%) PLK1;CDC20;MAD2L1;...
Proteasome 1.91 5.88e-4 44/46 (95.65%) PSMC3;PSMD1;IFNG;...
Ribosome biogenesis in eukaryotes 1.83 3.26e-3 52/108 (48.15%) NHP2;NOP56;FBL;...
RNA transport 1.74 1.46e-2 128/186 (68.82%) TACC3;NUP107;FUS;...
Non-homologous end-joining 1.72 1.60e-2 11/13 (84.62%) FEN1;XRCC5;DNTT;...
Drug metabolism 1.68 2.56e-2 78/151 (51.66%) RRM2;RRM1;NME4;...
Ubiquinone and other terpenoid-quinone biosynthesis 1.63 4.07e-2 9/11 (81.82%) COQ2;COQ3;COQ6;...
Cardiac muscle contraction 1.61 4.35e-2 64/87 (73.56%) TPM2;TNNC1;ACTC1;...
Glycosphingolipid biosynthesis -1.69 3.52e-2 37/57 (64.91%) B3GALNT1;ST3GAL1;ST3GAL4;...
Tuberculosis -1.70 2.88e-2 159/180 (88.33%) NOD2;CARD9;TRAF6;...
Phospholipase D signaling pathway -1.73 2.06e-2 134/148 (90.54%) AGTR1;RHEB;RALGDS;...
Sphingolipid signaling pathway -1.74 2.22e-2 106/119 (89.08%) NSMAF;PIK3CD;PPP2CB;...
Ferroptosis -1.77 1.86e-2 36/41 (87.8%) GCLC;ACSL3;GCLM;...
Selenocompound metabolism -1.78 1.91e-2 11/17 (64.71%) PAPSS1;SEPHS2;CTH;...
Phosphatidylinositol signaling system -1.81 7.86e-3 82/97 (84.54%) PIKFYVE;PIK3R2;INPP1;...
Synaptic vesicle cycle -1.83 8.73e-3 63/78 (80.77%) ATP6V1F;ATP6V0A2;STX2;...
Sphingolipid metabolism -1.88 3.27e-3 32/49 (65.31%) SGPL1;SPTLC1;GAL3ST1;...
Inositol phosphate metabolism -1.90 1.87e-3 66/73 (90.41%) INPP1;PI4KB;PIK3CA;...
Other glycan degradation -1.91 2.18e-3 13/18 (72.22%) NEU1;GLB1;ENGASE;...
Autophagy -1.94 2.62e-3 113/169 (66.86%) STK11;IRS1;TRAF6;...
Phagosome -1.98 3.27e-3 118/152 (77.63%) SEC61A2;DYNC1LI1;M6PR;...
Collecting duct acid secretion -1.99 4.37e-3 22/27 (81.48%) ATP6V1F;ATP6V0A2;ATP6V1E1;...
mTOR signaling pathway -2.01 6.55e-3 114/154 (74.03%) BRAF;ATP6V1D;CAB39L;...
Lysosome -2.31 0.00e+0 115/128 (89.84%) CTSO;CTSV;CLTC;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H