Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCIJBH)

Drug Name
DU-176b Drug Info
Synonyms Edoxaban
Cross-matching ID
PubChem CID
25022378
ChEBI ID
CHEMBL85974
CAS Number
CAS 1229194-11-9
TTD Drug ID
D0C3BS
VARIDT Drug ID
DR00166
INTEDE Drug ID
DR0558

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycolysis / Gluconeogenesis 2.17 0.00e+0 56/67 (83.58%) GAPDH;PKM;GPI;...
Steroid biosynthesis 2.03 5.64e-3 19/20 (95%) SQLE;DHCR7;CYP24A1;...
Central carbon metabolism in cancer 1.86 1.50e-2 67/70 (95.71%) PKM;PGAM1;SIRT3;...
Malaria 1.82 3.10e-2 44/50 (88%) COMP;TGFB1;ACKR1;...
ECM-receptor interaction 1.80 3.39e-2 80/88 (90.91%) SPP1;COMP;COL4A3;...
Pentose phosphate pathway 1.76 3.95e-2 25/30 (83.33%) GPI;ALDOA;TALDO1;...
Vitamin digestion and absorption -1.77 1.56e-2 17/24 (70.83%) SLC19A2;APOB;APOA1
Peroxisome -1.78 1.72e-2 72/82 (87.8%) ACSL6;AGXT;PEX12;...
Cholesterol metabolism -1.79 1.91e-2 44/50 (88%) ANGPTL3;ABCA1;ANGPTL4;...
Retinol metabolism -1.81 1.70e-2 41/68 (60.29%) CYP26A1;PNPLA4;CYP2C8;...
Alanine, aspartate and glutamate metabolism -1.82 1.94e-2 27/37 (72.97%) ALDH4A1;GFPT2;ASPA;...
Complement and coagulation cascades -1.89 1.06e-2 76/85 (89.41%) CFHR5;CFD;F2;...
Drug metabolism -1.98 0.00e+0 78/151 (51.66%) MAOA;CYP2D6;CMPK1;...
Nitrogen metabolism -2.02 0.00e+0 16/17 (94.12%) CPS1;GLUD2;GLUD1;...
Porphyrin and chlorophyll metabolism -2.05 0.00e+0 23/43 (53.49%) BLVRA;ALAS1;HCCS;...
Renin-angiotensin system -2.07 0.00e+0 20/23 (86.96%) ACE2;ATP6AP2;CTSA;...
Mineral absorption -2.33 0.00e+0 48/60 (80%) SLC26A3;ATP2B1;STEAP1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H